Lost in Translation? Finding Our Way To Effective Alzheimer's Disease Therapies

Journal of Alzheimer's Disease : JAD
Joseph F Quinn

Abstract

Efforts over the past two decades to develop effective disease-modifying treatments for Alzheimer's disease have been disappointing, while parallel efforts in another chronic neurologic disease, multiple sclerosis, have been remarkably productive. In an effort to advance development of therapeutics for Alzheimer's disease, these two fields are contrasted in terms of the utility of animal models, definition of study populations, and utility of biomarkers. Possible solutions are suggested, and the review concludes with description of some active peer-reviewed, publicly funded clinical studies which address some of the identified weaknesses in past clinical trials for age-related dementia.

References

Jun 5, 2003·JAMA : the Journal of the American Medical Association·Paul S AisenUNKNOWN Alzheimer's Disease Cooperative Study
Jul 23, 2003·Archives of Neurology·Martha Clare MorrisJulie Schneider
Mar 27, 2007·Journal of the American Society for Mass Spectrometry·Randall J BatemanKevin E Yarasheski
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kim N GreenFrank M LaFerla
Nov 14, 2007·Neurology·P Barberger-GateauA Alpérovitch
Oct 16, 2008·JAMA : the Journal of the American Medical Association·Paul S AisenUNKNOWN Alzheimer Disease Cooperative Study
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Marc FisherUNKNOWN STAIR Group
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Nov 4, 2010·JAMA : the Journal of the American Medical Association·Joseph F QuinnPaul S Aisen
Dec 15, 2010·Science·Kwasi G MawuenyegaRandall J Bateman
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Oct 6, 2011·Journal of Alzheimer's Disease : JAD·Eric M ReimanPierre N Tariot
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Jan 23, 2014·Journal of Alzheimer's Disease : JAD·Nora E GrayAmala Soumyanath
Jan 9, 2015·Neurology·Isaac Mawusi AdanyeguhFanny Mochel
Jan 31, 2015·Journal of Alzheimer's Disease : JAD·Nora E GrayAmala Soumyanath
Jan 20, 2016·Journal of Ethnopharmacology·Nora E GrayAmala Soumyanath
Jul 1, 2016·Alzheimer's Research & Therapy·Hussein N YassineLon S Schneider
Sep 2, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Randall J BatemanUNKNOWN DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network
Jul 19, 2017·Journal of Extracellular Vesicles·Julie A SaugstadFred H Hochberg
Sep 9, 2017·Oxidative Medicine and Cellular Longevity·Nora E GrayAmala Soumyanath
Jun 17, 2016·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kaushik GhosalGary E Landreth

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Citations

Jul 11, 2019·European Journal of Pharmacology·Désirée H Veening-GriffioenHuub Schellekens

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