Lot-to-lot variability of antibiotic medium 3 used for testing susceptibility of Candida isolates to amphotericin B.

Journal of Clinical Microbiology
M Lozano-ChiuJ H Rex

Abstract

We have previously shown that use of antibiotic medium 3 in the microdilution variant of the M27-T test method permits detection of amphotericin B-resistant Candida isolates. As this medium is not standardized and our initial work used only a single lot of antibiotic medium 3, we studied the lot-to-lot variability of three commercial lots of antibiotic medium 3 obtained from two sources. The MICs obtained with the new lots were lower than those of with the original lot, but the new lots still consistently separated putatively resistant and putatively susceptible isolates and this permits proposal of possible breakpoints for this assay system.

References

Apr 1, 1995·Antimicrobial Agents and Chemotherapy·J H RexE J Anaissie
Aug 1, 1994·The Journal of Infectious Diseases·E J AnaissieV Paetznick

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Citations

Aug 15, 2001·Pharmacotherapy·H L Hoffman, M A Pfaller
Jun 16, 2001·Antimicrobial Agents and Chemotherapy·M Cuenca-EstrellaJ L Rodríguez-Tudela
Nov 19, 2003·Current Opinion in Infectious Diseases·Ana Espinel-Ingroff
Oct 5, 2001·Clinical Microbiology Reviews·J H RexD W Warnock
Sep 22, 2007·Medical Mycology·Sevtap Arikan
Aug 7, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Edinaira Sulany Oliveira de SousaJoão Vicente Braga de Souza
Jan 4, 2001·Journal of Clinical Microbiology·F PeyronA Bolmström
Aug 31, 2021·Diagnostic Microbiology and Infectious Disease·Edinaira Sulany Oliveira de SousaJoão Vicente Braga de Souza

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