Loudness dependence of auditory evoked potentials (LDAEP) in clinical monitoring of suicidal patients with major depression: a pilot study.

European Archives of Psychiatry and Clinical Neuroscience
Idun UhlG Juckel

Abstract

Loudness dependence of auditory evoked potentials (LDAEP) is a validated in vivo marker of central serotonergic function. We aimed at measuring serotonergic activity in a follow-up study of suicidal patients. It should be investigated whether suicide attempts or suicidal states cause changes in the LDAEP. Thirteen patients (mean age, 40.9 ± 11.3 years; age range, 20-61, 6 male) with a major depressive episode who had attempted suicide or had suicidal plans (Hamilton Depression Rating Scale item 3 [suicidality] ≥3) were included in the study. LDAEP and psychometric measurements took place about 2, 5, 9 and 16 days after attempted suicide or suicidal action. On day 9, LDAEP was significantly higher compared to day 2 and day 16; there was a similar tendency compared to day 5. Instability of central serotonergic function is suggested resulting in reduced serotonergic activity about 1 week after suicide attempt. Further studies are necessary that include larger samples in order to distinguish between different psychiatric diseases and to consider confounding factors like gender, smoking, medication, impulsivity or lethality of suicidal action.

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Citations

May 29, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung-Hwan LeeSang Woo Hahn
Jan 15, 2013·Journal of Affective Disorders·Do-Hyung Kim, Young-Min Park
Dec 3, 2016·Scientific Reports·Ji Sun KimSeung-Hwan Lee
Jan 1, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M S ZinchukM N Grishkina
Apr 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mingyu HwangSang-Woo Hahn

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