PMID: 7522603Jan 1, 1994Paper

Lovastatin inhibits HIV-1 expression in H9 human T lymphocytes cultured in cholesterol-poor medium

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
J C MazièreD Zagury

Abstract

The effects of the HMG-Coenzyme A reductase inhibitor lovastatin on HIV-1 expression and sterol synthesis have been investigated in the human H9 lymphocytic cell line. To this purpose, sterol synthesis from 14C-acetate, cell multiplication and reverse transcriptase activity have been measured in parallel at various times after cell infection by HIV-1. It was found that nine days after viral loading, lovastatin inhibited both sterol synthesis and viral multiplication as assessed by the reverse transcriptase activity. Since HIV infection has been shown to induce alterations in membrane cholesterol content, suggesting that the virus cycle may be partially dependent upon cellular cholesterol, inhibitors of cholesterol synthesis could be an interesting way of research in order to slower HIV propagation.

Associated Clinical Trials

Jul 24, 2008·Carlos Julio Montoya Guarin

References

Feb 1, 1992·AIDS Research and Human Retroviruses·E De Clercq
Sep 1, 1991·AIDS Research and Human Retroviruses·J J AguilarJ Uriel
Dec 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W A Maltese
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R C AloiaL M Gordon
Aug 1, 1987·Journal of Biochemical and Biophysical Methods·C MazièreJ Polonovski
Sep 1, 1984·The Journal of Clinical Investigation·T S ParkerP J De Schepper

❮ Previous
Next ❯

Citations

Feb 12, 2011·Archives of Virology·Hiroshi FujitaYasufumi Kaneda
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Trevor D BurtSunil K Ahuja
Aug 18, 2004·The Journal of Experimental Medicine·Gustavo del RealSantos Mañes
Oct 11, 2005·Viral Immunology·Caroline GilbertMichel J Tremblay
Jan 27, 2011·The Journal of Infectious Diseases·Andrew Carr
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Nathalie Chazal, Denis Gerlier
Mar 25, 2005·Journal of Negative Results in Biomedicine·Nusrat ShafiqAnil Grover
Nov 2, 2006·PLoS Biology·Zahedi MujawarDmitri Sviridov
Oct 23, 2012·The Journal of Infection·Carlos J MontoyaFabian A Jaimes
Jul 6, 2010·Virus Research·Ann S DesplanquesHerman W Favoreel
Jun 24, 2014·Chemical Biology & Drug Design·Angela T HarrisonRaymond Hewer
Jul 2, 2015·Current HIV/AIDS Reports·Allison Ross Eckard, Grace A McComsey
Jul 17, 2015·Canadian Journal of Microbiology·Ragunath SingaraveluJohn Paul Pezacki
Aug 23, 2001·Current Biology : CB·Y H ZhengB M Peterlin
Dec 29, 1998·Antiviral Chemistry & Chemotherapy·C MoogB Luu
Mar 2, 2017·PloS One·Henning DrechslerRoger Bedimo
Oct 24, 2006·Journal of Leukocyte Biology·Michael Bukrinsky, Dmitri Sviridov
Jul 25, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Roger J BedimoUNKNOWN A5321 Study Team
May 3, 2018·MBio·Punya Shrivastava-RanjanChristina F Spiropoulou
Nov 24, 2020·Journal of Cardiac Surgery·Santoshi K AshwithaAmer Harky
May 22, 2021·Frontiers in Pharmacology·Xinlei Li, Tao Peng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.