Lovastatin-producing endophytic fungus isolated from a medicinal plant Solanum xanthocarpum

Natural Product Research
Ramalingam Parthasarathy, Muthukrishnan Sathiyabama

Abstract

Lovastatin is a potent drug for lowering blood cholesterol. An endophytic fungus Phomopsis vexans was isolated from the healthy leaf tissues of Solanum xanthocarpum, a medicinal plant, and screened for lovastatin production. The fungus was identified by their characteristic cultural morphology and molecular analysis. The strain had a component with the same TLC Rf value and HPLC retention time as authentic lovastatin. The presence of lovastatin was further confirmed by FT-IR, UV, (1)H, (13)C NMR and LC-MS analyses. The amount of lovastatin produced by this endophytic fungus was quantified to be 550 mg/L, and thus the fungus can serve as a potential material to improve the production of lovastatin.

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Citations

Jun 4, 2016·Genome Announcements·J SavithaV K Praveen
Oct 17, 2017·Natural Product Research·Muthukrishnan Sathiyabama, Ramalingam Parthasarathy
May 9, 2019·Microorganisms·Chandra RisdianJoachim Wink
Feb 9, 2017·Applied Microbiology and Biotechnology·Rabia TanvirAamir Ghafoor Bajwa
May 24, 2017·Natural Product Research·Seham S El-HawaryRabab Mohammed
Mar 7, 2021·Journal of Fungi·Bartholomew Saanu Adeleke, Olubukola Oluranti Babalola
May 6, 2021·Natural Product Research·Youjuan ZhuXiachang Wang

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Datasets Mentioned

BETA
KF727287

Methods Mentioned

BETA
NMR

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