Abstract
Upper limb botulinum toxin A doses in children are empirical, determined by the size of the muscle, seeking to avoid excessive weakness and deterioration of function. This study reports the effects and side effects of botulinum toxin treatment on upper limb impairment and function in 18 children with spastic or dystonic hyperactivity. A total of 54 treatments were divided into low-dose or high-dose groups according to the dose used for the target muscles. The outcome measurements included modified Ashworth Scale, passive range of movement, various grips, bimanual functions, movement pattern, House classification of upper extremity use, and subjective ratings of function and cosmetic appearance. In the functional goal group, children benefited in terms of reduction in muscle tone at elbow and wrist, and increase in passive wrist extension and House classification scores. A significant difference between the groups was observed in the House classification, favoring the low-dose group. In the nonfunctional goal group, a significant difference was detected in subjective parental cosmetic ratings, favoring the high dosage. Side effects were few and occurred mostly in the high-dose group. In conclusion, the use of higher doses in the...Continue Reading
References
Feb 1, 1981·The Journal of Bone and Joint Surgery. American Volume·J H HouseM O Fidler
Jul 1, 1993·Journal of Pediatric Orthopedics·L A KomanT Mulvaney
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A de PaivaJ O Dolly
Feb 9, 2000·Gait & Posture·H K GrahamJ Wissel
Mar 4, 2000·American Journal of Physical Medicine & Rehabilitation·A FriedmanC Daffner
Apr 25, 2000·Neuropediatrics·I Autti-RämöL von Wendt
Sep 2, 2000·The Journal of Pediatrics·D FehlingsC Steele
Apr 18, 2001·Developmental Medicine and Child Neurology·A M BakheitS H Rousso
Feb 20, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I Autti-RämöL von Wendt
Mar 15, 2003·Archives of Physical Medicine and Rehabilitation·Edward A HurvitzSusan H Brown
Mar 22, 2003·American Journal of Physical Medicine & Rehabilitation·Tsui Fen YangShu Jen Chen
Feb 18, 2004·Archives of Physical Medicine and Rehabilitation·Margaret A WallenMary-Clare A Waugh
Jul 3, 2004·Developmental Medicine and Child Neurology·Rosalind J Jefferson
Citations
Feb 26, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yajie Wang, Baoqin Gao
Nov 16, 2013·World Journal of Pediatrics : WJP·Ya-Jie Wang, Bao-Qin Gao
Jun 6, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christopher Y ChangJames P Thomas
Nov 14, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Mieke B J Moerman
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D FehlingsUNKNOWN Cerebral Palsy Institute
Oct 27, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Teressa Garcia ReidyAnne M Comi
Oct 6, 2011·International Journal of Pediatric Otorhinolaryngology·Melynda A BarnesAnna Messner
Apr 20, 2011·International Journal of Pediatric Otorhinolaryngology·Anna MessnerMelynda A Barnes
Nov 17, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Florian HeinenGuy Molenaers
Apr 26, 2008·Scandinavian Journal of Medicine & Science in Sports·E OskarssonK Pettersson
Aug 20, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Urban M FietzekSteffen Berweck
Jan 12, 2010·Developmental Medicine and Child Neurology·Susan GreavesLena Krumlinde-Sundholm
Nov 14, 2006·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Florian HeinenIngeborg Krägeloh-Mann
Apr 23, 2016·Developmental Medicine and Child Neurology·Aysu KahramanAkmer Mutlu
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Brian J HoareLeeanne Carey
Nov 6, 2007·Developmental Medicine and Child Neurology·Kevin LoweAnne Cusick
Sep 30, 2015·Annals of Plastic Surgery·Katherine J FuMatthew R Greives
Aug 28, 2020·Medicine·Melanie A MorscherMark J Adamczyk
Jun 15, 2007·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·M Rousseaux, W Daveluy
Jun 15, 2007·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·P Filipetti, F Chantraine
Sep 25, 2021·PM & R : the Journal of Injury, Function, and Rehabilitation·Joshua A VovaMatthew J McLaughlin