Low- and high-frequency electric cortical stimulation suppress the ferric chloride-induced seizures in rats

Neuroscience Letters
Qing-He YaoGuo-Dong Gao

Abstract

The clinic treatment of epilepsy with epileptic foci overlapped with eloquent cortex is not satisfactory. In this study we investigated the direct effects of low- and high-frequency electric cortical stimulation (ECS) on ferric chloride-induced seizures in the experimental rats. Results showed that spontaneous seizures were observed in all rats during the EEG recording after the intracortical injection of ferric chloride solution into left sensorimotor cortex. One-hertz or 100-Hz ECS with 0.3 ms duration and 0.1 mA amplitude square pulses in 1h on the cortical lesioned area significantly decreased the number of seizures compared with that of the non-stimulation control group. The mean duration time of seizures in 1-Hz or 100-Hz groups was apparently shorter than that in the control group. In brief, this study showed that both low- and high-frequency ECS suppressed the seizures induced by ferric chloride in rats, indicating their potential treatment effects on epilepsy in clinic.

References

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Apr 1, 1996·The European Journal of Neuroscience·G Hess, J P Donoghue
Apr 27, 2002·Experimental Brain Research·Anatol BraginJerome Engel
Jul 13, 2004·Epilepsy Research·M L López-MerazL Rocha
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gonzalo Alarcón
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masako KinoshitaHiroshi Shibasaki
Feb 7, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lara M SchraderItzhak Fried

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