Abstract
In a prospective, nonrandomized trial clinical (initial WBC and chest film) and immunological (surface immunoglobulin and rosetting with pretreated sheep red blood cells) criteria were used to stratify 69 children with previously untreated acute lymphoid leukemia (ALL). Forty of 61 evaluable patients had low-risk ALL (initial WBC less than or equal to 20,000/mm3, no mediastinal mass) and were treated less intensively. Twenty-one of 61 patients had high-risk ALL (initial WBC greater than 20,000/mm3 and/or mediastinal mass) and were treated more intensively. Of the high-risk patients 15 had non-T non-B and 6 T ALL. Sixty of 61 patients went into complete remission. After a median observation period of 27 months, 32 of 40 low-risk, 7 of 14 high-risk non-T non-B, and none of 6 high-risk T ALL patients were in continuous first remission. Thirty-six of 40 low-risk, 9 of 15 high-risk non-T non-B, and none of 6 T ALL patients were alive. Despite more intensive treatment, the duration of remission and the survival were significantly shorter in the high-risk than in the low-risk patients. Among the high-risk ALL, non-T non-B ALL did better than T ALL.
References
Dec 24, 1977·Lancet·J M ChessellsM F Greaves
Jan 1, 1978·British Journal of Haematology
Aug 1, 1976·British Journal of Haematology·J M BennettC Sultan
Mar 2, 1978·The New England Journal of Medicine·R B EllisM F Greaves
Apr 20, 1978·The New England Journal of Medicine·L B VoglerM D Cooper
Jan 1, 1979·American Journal of Hematology·R B RaneyH W Hann
Jul 1, 1978·Cancer·A H WilliamsR J Lukes
Aug 1, 1978·Cancer·J C Brouet, M Seligmann
Jan 1, 1979·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·A V HoffbrandG Janossy
Dec 1, 1976·British Journal of Cancer·R PetoP G Smith
Apr 17, 1975·The New England Journal of Medicine·L Sen, L Borella
Jul 1, 1976·British Journal of Haematology·J C BrouetM Seligmann
Apr 1, 1980·British Journal of Obstetrics and Gynaecology
Feb 1, 1980·British Journal of Haematology·M De BruyèreG Sokal
Mar 1, 1980·British Journal of Haematology·M B VianaC Ferenc
Jan 1, 1980·Medical and Pediatric Oncology·W M CristG Merijanian
Feb 1, 1980·British Journal of Haematology·G JanossyT A Lister
May 1, 1980·British Journal of Haematology·J V Simone
May 1, 1980·Pediatric Clinics of North America·D R Miller
Jan 1, 1980·Medical and Pediatric Oncology·A T MeadowsD Hammond
Citations
Nov 1, 1983·Human Immunology·V E Von FliednerM Wyss
Jul 24, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K C BholA R Ahmed
May 1, 1985·Blut·V HachC Mueller-Eckhardt
Jun 1, 1983·Blut·C WenskeC Lauritzen
Jun 1, 1984·Blut·T W JungiS Barandun
Jun 1, 1984·Blut·D Sidiropoulos, B Straume
Jun 1, 1984·Blut·E SeifriedH Rasche
Feb 6, 2002·Springer Seminars in Immunopathology·L RauovaY Shoenfeld
Sep 26, 2006·Journal of Neurology·Martin Stangel, Refik Pul
Sep 20, 2008·Journal of Neurology·Hans-Peter Hartung
Sep 20, 2008·Journal of Neurology·Richard Hughes
Jan 1, 1982·Leukemia Research·B RamotS Orgad