Low 25-hydroxyvitamin D level and adiponectin is associated with insulin sensitivity in large gestational age infants

Cytokine
Ferhat CekmezSerdar Umit Sarici

Abstract

To investigate the relationship between adipokines (visfatin, adiponectin) and 25-hydroxyvitamin D (25(OH)D), and markers of insulin sensitivity in large for gestational age (LGA) infants. Forty LGA infants (25 LGA born to diabetic mothers and 15 LGA born to non-diabetic mothers) and 34 appropriate for gestational age (AGA) infants were recruited. FGIR, QUICK-I, adiponectin and 25(OH)D levels were significantly lower in LGA with diabetic mother group than AGA and LGA with non-diabetic mother group. HOMA-IR, fasting insulin, visfatin and parathormone (PTH) levels were significantly higher in LGA with diabetic mother group than AGA and LGA with non-diabetic mother group. Based on the findings of this study, visfatin, adiponectin and 25(OH)D levels can be used as specific markers for insulin sensitivity and may help advance new therapies for glucose intolerance spectrum.

References

Nov 25, 2000·Metabolism: Clinical and Experimental·K C ChiuM F Saad
Sep 2, 2003·Cytokine & Growth Factor Reviews·Hong Ruan, Harvey F Lodish
Oct 2, 2004·Obstetrics and Gynecology·Pamela J SurkanSven Cnattingius
Dec 18, 2004·Science·Atsunori FukuharaIichiro Shimomura
Jan 19, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S LihnB Richelsen
Jan 6, 2006·The Journal of Clinical Endocrinology and Metabolism·Ann HammarstedtUlf Smith
Mar 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Zubin PunthakeeMarie Lambert
Feb 3, 2007·Mini Reviews in Medicinal Chemistry·S KralischM Fasshauer
Feb 15, 2007·Obesity·Xiaocun Sun, Michael B Zemel
Mar 18, 2009·European Journal of Endocrinology·Marie-Hélène Gannagé-YaredGeorges Halaby
May 22, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Cihan MeralIsmail Gocmen
Jan 29, 2011·Journal of Clinical Research in Pediatric Endocrinology·Behzat ÖzkanHalil Keskin
Jan 29, 2011·Journal of Clinical Research in Pediatric Endocrinology·Ayça Törel ErgürGönül Öcal
Mar 19, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Richard Ivell, Ravinder Anand-Ivell

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Citations

Jul 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Yu DongUNKNOWN 3D Cohort Study Group
Sep 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Rong HuangZhong-Cheng Luo

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