Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Denise K HoustonHealth ABC Study

Abstract

Although low 25-hydroxyvitamin D (25(OH)D) is prevalent among older adults and is associated with poor physical function, longitudinal studies examining vitamin D status and physical function are lacking. We examined the association between 25(OH)D, parathyroid hormone (PTH), and the onset of mobility limitation and disability over 6 years of follow-up in community-dwelling, initially well-functioning older adults participating in the Health, Aging and Body Composition study (n = 2,099). Serum 25(OH)D and PTH were measured at the 12-month follow-up visit (1998-1999). Mobility limitation and disability (any/severe difficulty walking 1/4 mile or climbing 10 steps) was assessed semiannually over 6 years of follow-up. The association between 25(OH)D, PTH, and mobility limitation and disability was examined using Cox proportional hazard regression models adjusted for demographics, season, behavioral characteristics, and chronic conditions. At baseline, 28.9% of the participants had 25(OH)D <50 nmol/L and 36.1% had 25(OH)D of 50 to <75 nmol/L. Participants with 25(OH)D <50 and 50 to <75 nmol/L were at greater risk of developing mobility limitation (HR (95% CI): 1.29 (1.04-1.61) and 1.27 (1.05-1.53), respectively) and mobility disabil...Continue Reading

References

Jan 1, 1996·Annual Review of Public Health·J M GuralnikM E Salive
Jan 23, 1999·Archives of Physical Medicine and Rehabilitation·H A BischoffR Theiler
Feb 13, 1999·Journal of the American Geriatrics Society·M MowéT Bøhmer
Aug 25, 2001·Journal of Clinical Epidemiology·L P FriedUNKNOWN WHAS II Collaborative Research Group
Oct 5, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E M SimonsickUNKNOWN Health ABC Study Group
Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mauro ZamboniOttavio Bosello
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J K DhesiT J Allain
May 25, 2002·Journal of the American Geriatrics Society·René VerreaultJack M Guralnik
Jul 12, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G IsaiaS Adami
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Marjolein VisserUNKNOWN Longitudinal Aging Study Amsterdam
Aug 24, 2004·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Mar 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P GerdhemK Akesson
Jun 29, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Susan L GreenspanRobert A Parker
Jun 22, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K A FaulknerM C Nevitt
Jul 11, 2006·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Ilse S WichertsPaul Lips
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Denise K HoustonStephen B Kritchevsky
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jan 24, 2008·JAMA : the Journal of the American Medical Association·Benedetta BartaliThomas M Gill
Aug 30, 2008·Molecular Aspects of Medicine·Lisa Ceglia
Sep 20, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T-T L DamE L Barrett-Connor
Nov 21, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Paul MuntnerMary B Leonard
Feb 26, 2010·The Journal of Nutrition·Regan L BaileyMary Frances Picciano
Apr 28, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesN Yoshimura
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Sep 20, 2011·Journal of Women's Health·Yvonne L MichaelJoAnn E Manson
Nov 19, 2011·Journal of the American Geriatrics Society·Denise K HoustonStephen B Kritchevsky

❮ Previous
Next ❯

Citations

Mar 6, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marco MoseleGiuseppe Sergi
Jun 6, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elena D ToffanelloEnzo Manzato
Nov 12, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Luis Miguel Gutiérrez-RobledoNora Magdalena Torres-Carrillo
Mar 5, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Andrea P RossiMauro Zamboni
May 21, 2013·Annals of the New York Academy of Sciences·Sylvia ChristakosDaniel D Bikle
Apr 5, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Violet LagariSilvina Levis
Aug 10, 2013·Journal of the American Geriatrics Society·Jatupol KositsawatGeorge A Kuchel
Jun 14, 2014·Journal of the American Geriatrics Society·Daniel S Kemp
Jan 19, 2016·Current Nutrition Reports·Denise K Houston
Mar 4, 2015·The Journal of Nutrition, Health & Aging·M BonnefoyY Rolland
Mar 7, 2014·Journal of Nutrition in Gerontology and Geriatrics·Alyson HaslamUNKNOWN Georgia Centenarian Study
Mar 10, 2016·Cadernos de saúde pública·Rodrigo Zunzarren MegaleSérgio Viana Peixoto
Oct 9, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Karolina BrookSadeq A Quraishi
May 6, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Kyla SheaSarah L Booth
Nov 20, 2016·Journal of the American Geriatrics Society·Silvina Levis, Orlando Gómez-Marín
Dec 15, 2018·Salud pública de México·José Rodolfo Torres-de AraújoKenio Costa-de Lima
Jan 18, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D LelliM Inzitari
Jan 31, 2019·The Journal of Nutrition, Health & Aging·Y YaoY He
Jan 31, 2020·Ageing Research Reviews·Richard D SembaLuigi Ferrucci
Aug 6, 2018·Journal of the American Medical Directors Association·Flávia Silva Arbex BorimCesar de Oliveira
Oct 28, 2018·Journal of the American Medical Directors Association·Mia-Maria PeräläJohan G Eriksson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.