PMID: 8584242Oct 20, 1995Paper

Low-affinity nerve growth factor receptor expression in sciatic nerve during P2-peptide induced experimental allergic neuritis

Neuroscience Letters
G ContiG Scarlato

Abstract

Northern blot, immunocytochemistry, and single nerve fiber immunostaining were used to determine the expression of low-affinity nerve growth factor (NGF) receptor (p75NGFR) in the peripheral nervous system of Lewis rats during the course of experimental allergic neuritis (EAN) induced with 100 micrograms of 'SP26' synthetic peptide, corresponding to residues 53-78 of bovine P2 myelin protein. This severe reversible polyneuropathy, characterized by extensive multifocal demyelination in nerve roots, and axonal degeneration within sciatic nerve, represents a useful tool to investigate Schwann cell gene expression in these different pathological conditions. Our results showed that both p75NGFR mRNA and protein were induced within sciatic nerve by day 18 and 23 after 'SP26' immunization. By this time, however, p75NGFR was not detectable in roots of cauda equina. These data demonstrate that, during EAN induced by immunization with 100 micrograms of 'SP26', p75NGFR is up-regulated in Schwann cells and in nerve fibers distally along the nerve. This suggests that the induction of the receptor in sciatic nerve during P2-peptide EAN is related to the loss of axonal contact by Schwann cells.

References

Jan 1, 1992·Journal of Neuroscience Research·X Fan, B B Gelman
Jul 1, 1990·Muscle & Nerve·J L RosenA Rostami
Jul 1, 1987·Journal of the Neurological Sciences·P MilnerR A Hughes
Jul 1, 1988·Annals of Neurology·G SobueD Pleasure
Oct 1, 1988·Journal of Neuroscience Research·K MokunoD Pleasure
Dec 1, 1984·Annals of Neurology·A RostamiD E Pleasure

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Citations

Oct 13, 2001·Journal of Neuroscience Research·M ScarlatoD Pleasure
Jan 8, 1999·Journal of the Neurological Sciences·G ContiG Scarlato
Aug 18, 1999·Journal of the Neurological Sciences·C A VedelerA Rostami
Dec 5, 1997·Brain Research. Molecular Brain Research·A D ToewsP Morell
Sep 18, 2007·Journal of the Peripheral Nervous System : JPNS·Guido CavalettiGiovanni Tredici
May 2, 2003·Journal of Neuropathology and Experimental Neurology·Steven PetratosTrevor J Kilpatrick

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