PMID: 9556031Apr 29, 1998Paper

Low affinity NGF receptor expression in the central nervous system during experimental allergic encephalomyelitis

Journal of Neuroscience Research
S NatafC N Montero-Menei

Abstract

In the central nervous system (CNS), p75, or low-affinity nerve growth factor receptor (LNGFR), is assumed to play a critical role in mediating the effects of neurotrophins on neuronal survival. Recent studies have shown that nerve growth factor (NGF) can act also on immune cells through its binding to p75. Using immunohistochemistry, we have investigated the expression of the p75 receptor in the CNS during chronic relapsing experimental allergic encephalomyelitis (EAE) of the Lewis rat, an animal model of multiple sclerosis (MS). We report here a sequential expression of p75, first in Purkinje cells during the first attack, and secondly on both endothelial and perivascular cells in the latter stages of the disease. Moreover, starting from the second attack, p75 was also expressed on glial ensheathing cells, likely myelinating cells, located primarily in the dorsal roots. These data suggest that during EAE, LNGFR may play an important role in leukocyte-endothelial cell interactions and in the maintenance of Purkinje cells survival.

Citations

Feb 7, 2002·Journal of Neuropathology and Experimental Neurology·Paola ValdoBruno Bonetti
Nov 12, 2005·Neuropathology and Applied Neurobiology·J C V M CoprayH W G M Boddeke
Jan 31, 2020·Journal of Neuroinflammation·Nickoleta DelivanoglouConstantina Simeonidou
Nov 10, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Franc LlorensJosé Antonio del Río
Feb 19, 2008·Journal of Molecular Neuroscience : MN·T Zeis, N Schaeren-Wiemers
May 27, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Liborio RampelloFerdinando Nicoletti

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