Low age adjusted free testosterone levels correlate with poorly differentiated prostate cancer

The Journal of Urology
Ignacio F San FranciscoAria F Olumi

Abstract

We determined the relationship between age adjusted free T, and stage, grade and the biochemical-free survival rate in patients with surgically treated prostate cancer. A retrospective cohort study was done between 1995 and 2001 in 333 patients treated for clinically localized prostate cancer with radical retropubic prostatectomy by a single surgeon at our institution. The study cohort consisted of 279 patients (84%) who had free T levels available. Free T was assessed by single cutoff value of 1.5 ng/dl or less, as suggested by the assay manufacturer, or by age adjusted free T. The relationship of low free T as a single cutoff value and age adjusted reference ranges with clinical and pathological measures of disease progression were assessed using the Fisher exact and Wilcoxon rank sum tests with the outcome assessed by the log rank test. Using the assay manufacturer suggested single cutoff value of 1.5 ng/dl or less to define low free T 57% of patients with prostate cancer in the cohort were categorized as hypogonadal. However, using age adjusted free T reference ranges only 2.5% of patients with prostate cancer were categorized as hypogonadal, which is more logical and representative of clinically significant hypogonadism in...Continue Reading

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Citations

Mar 9, 2007·International Journal of Clinical Practice·M M Miner, A D Seftel
Apr 10, 2007·Cancer Detection and Prevention·Yoshitaka SekineKazuhiro Suzuki
Mar 28, 2009·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Dominic Hodgson
Mar 18, 2008·The Journal of Urology·Ernani Luis RhodenAbraham Morgentaler
Dec 12, 2012·The Kaohsiung Journal of Medical Sciences·Cenk GurbuzTurhan Caskurlu
Nov 15, 2013·Journal of Cellular and Molecular Medicine·Ignacio F San FranciscoAlejandro S Godoy
Nov 11, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Adrian S Dobs, Abraham Morgentaler
May 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea SaloniaFrancesco Montorsi

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