Low B and T lymphocyte attenuator expression on CD4+ T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study

Critical Care : the Official Journal of the Critical Care Forum
Rui ShaoChenchen Hang

Abstract

B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early stage of sepsis with the severity and mortality of septic patients in the emergency department (ED). 336 consecutive patients were included in this study. BTLA expression on CD4(+) T cells was measured by flow cytometry within 24h of ED admission. Our results showed that the percentage of BTLA(+)/CD4(+) T cells was high expression in healthy volunteers and it was statistically reduced in severe sepsis and septic shock compared with healthy controls(all P<0.01). The area under the receiver operating characteristic (AUC) curves of BTLA expression on CD4(+) T cells was slightly lower than that of procalcitonin (PCT) and Mortality in Emergency Department Sepsis (MEDS) score. The percentage of BTLA(+)/CD4(+)T cells was lower in non-survivors than in survivors (P<0.01), and similar results were obtained when expressed as mean of fluorescence intensities (MFI) (P<0.01). Adjusted logistic regression analysis suggested that the percenta...Continue Reading

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Citations

Nov 20, 2016·European Journal of Clinical Investigation·María Ángeles Jiménez-SousaSalvador Resino
Jul 25, 2020·Critical Care Medicine·Lindsay M BuschParizad Torabi-Parizi
May 3, 2019·JCI Insight·Jianfeng XieMandy L Ford
Feb 14, 2021·International Reviews of Immunology·Yan-Cun LiuYan-Fen Chai
Apr 17, 2021·Frontiers in Immunology·Zhaochen NingHuabao Xiong
Jun 25, 2021·Frontiers in Immunology·Zheng DengZheng Zheng

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Methods Mentioned

BETA
PCT

Software Mentioned

SPSS
ENTER
Gallios

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