Low birth weight--is it associated with few and small glomeruli in normal subjects and NIDDM patients?

Diabetologia
J R NyengaardC E Mogensen

Abstract

These studies were undertaken to ascertain if there is any association between low birth weight, and low kidney weight, few and/or small glomeruli, in kidneys from a control group and a group of non-insulin-dependent diabetic (NIDDM) patients. The background for this study comes from findings suggesting a correlation between low birth weight and the development of NIDDM and high blood pressure. Furthermore, Brenner has postulated that humans born with a low number of glomeruli, thereby having a low glomerular filtration surface area, have a greater tendency to develop high blood pressure. We examined 79 autopsy kidneys, with known weight from normal and NIDDM patients, which had previously been used for studies of glomerular number and volume. In the archives of the Danish midwives we were able to find birth weight for 26 NIDDM patients and an age- and sex-matched sample of 19 control persons. The kidney weight (g) ( 137 +/- 36; NIDDM: 150 +/- 38; 2p = 0.26), glomerular number (10(3)) (CONTROL: 670 +/- 176; NIDDM: 673 +/- 200; 2p = 0.95), glomerular volume (10(6) micron3) (CONTROL: 6.25 +/- 1.48; NIDDM: 5.71 +/- 1.74; 2p = 0.28) or birth weight (g) ( 3577 +/- 400; NIDDM: 3489 +/- 429; 2p = 0.49) were not different between the g...Continue Reading

Citations

May 1, 1996·Journal of Diabetes and Its Complications·J S Yudkin
Apr 20, 2001·Diabetes Research and Clinical Practice·L T PijlsJ T van Eijk
Feb 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·C F ThompsonA Cecil
May 1, 2002·Current Opinion in Nephrology and Hypertension·Tivadar Tulassay, Barna Vásárhelyi
Feb 22, 2011·American Journal of Nephrology·Jane C TanBryan D Myers
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sarah L WhiteRachel R Huxley
Sep 29, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mandy G Keijzer-VeenBert J van der Heijden
Feb 13, 2010·Journal of the American Society of Nephrology : JASN·Valerie A Luyckx, Barry M Brenner
May 8, 1999·Journal of the American Society of Nephrology : JASN·J R Nyengaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.