Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease

Alimentary Pharmacology & Therapeutics
C L NobleJ Satsangi

Abstract

Osteoporosis is a recognized complication of inflammatory bowel disease (IBD). Aim To investigate the role of environmental factors and vitamin D receptor (VDR) variants on the prevalence of osteoporosis. DEXA scans and case note review were performed on 440 IBD patients from 1997 to 2006. All the IBD patients and 240 healthy controls were genotyped for VDR variants Taq-1 and Apa-1 using PCR-RFLP. Osteoporosis and osteopenia rates were 15% and 18% for IBD, 16% and 18% for Crohn's disease (CD) and 13% and 19% for ulcerative colitis, respectively. On univariate analysis of the CD patients, low body mass index (BMI, <18.5) and smoking status (P = 0.008 and 0.005 respectively) were associated with osteoporosis and osteopenia. Low BMI was also associated with osteoporosis on multivariate analysis in CD (P = 0.021, OR 5.83, CI 1.31-25.94). No difference was observed between Taq-1 and Apa-1 VDR polymorphisms in IBD, CD, ulcerative colitis and healthy controls. However, CD males were more likely to carry the variant Taq-1 polymorphism than healthy controls males (P = 0.0018, OR 1.94, CI 1.28-2.92) and female CD patients (P = 0.0061, OR 1.60, CI 1.17-2.44). In this well-phenotyped cohort of IBD patients, a relatively low prevalence of o...Continue Reading

References

Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J E Lennard-Jones
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Apr 1, 1987·Gut·J E CompstonJ Rhodes
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G S Cooper, D M Umbach
Mar 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·J S HyamsG A Gronowicz
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Sep 11, 1998·The American Journal of Gastroenterology·R D PollakD Rachmilewitz
Nov 21, 1998·Digestive Diseases and Sciences·R J RobinsonJ F Mayberry
May 29, 2002·European Journal of Human Genetics : EJHG·Sheila A FisherCathryn M Lewis
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ammarin ThakkinstianJohn Attia
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John A KanisDan Mellstrom
Apr 25, 2006·Lancet·Daniel R GayaJack Satsangi
Aug 16, 2006·Annals of Internal Medicine·André G UitterlindenUNKNOWN GENOMOS Study
Sep 19, 2006·Genes & Development·Stuart H Ralston, Benoit de Crombrugghe
Sep 29, 2006·World Journal of Gastroenterology : WJG·Sarah A BartramNick P Thompson
Jan 9, 2007·Inflammatory Bowel Diseases·Johan Van LimbergenJack Satsangi
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E Mullin, Adrian Dobs
Aug 1, 2007·Clinical Science·Peter K K WongJohn D Wark

❮ Previous
Next ❯

Citations

Apr 18, 2013·Inflammatory Bowel Diseases·Matthew T Palmer, Casey T Weaver
May 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mona H IsmailAbdulaziz Alquorain
Oct 28, 2014·Journal of Receptor and Signal Transduction Research·Sheng-Long XiaYi Jiang
Jun 13, 2012·Alimentary Pharmacology & Therapeutics·M GargP R Gibson
Mar 4, 2011·Alimentary Pharmacology & Therapeutics·R W BentleyA S Day
May 23, 2015·BioMed Research International·Marco ArdesiaWalter Fries
Dec 4, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E MullinKasia Kines
Sep 13, 2014·Inflammatory Bowel Diseases·Declan F McCole
Apr 1, 2018·Journal of Gastroenterology and Hepatology·Takeo NaitoTooru Shimosegawa
Aug 14, 2010·International Journal of Rheumatic Diseases·Yasser Ezzat, Khaled Hamdy
Aug 30, 2012·Expert Review of Gastroenterology & Hepatology·Michael Schultz, A Grant Butt
Jul 23, 2014·Expert Review of Gastroenterology & Hepatology·Simon Ghaly, Ian Lawrance
Aug 24, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Hideki IijimaTetsuo Takehara
Dec 19, 2019·International Journal of Molecular Sciences·Ke KeYousef Abu-Amer
Nov 12, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Aleksandra Szymczak-TomczakIwona Krela-Kaźmierczak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.