Low body weight and clinical outcomes in acute coronary syndrome patients: results of the ACHILLES Registry

European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology
José Miguel Rivera-CaravacaFrancisco Marín

Abstract

Being overweight increases the risk of cardiovascular diseases and mortality. However, among high-body-weight patients with established acute coronary syndrome (ACS) this evidence is not clear. In this scenario, a low body weight (LBW) has been proposed to confer higher prognostic risk and higher bleeding risk with new P2Y12 inhibitors. We aimed to examine differences in mortality, catheterizations/revascularizations, antiplatelet therapy and ischemic/bleeding adverse events between ACS patients with LBW. This is a multicenter registry involving 1576 consecutive ACS patients (ST-elevation myocardial infarction (STEMI), non-STEMI, or unstable angina) from three tertiary institutions. Patients were divided into two groups: LBW (weight < 60 kg, n = 176) and non-LBW (weight ⩾ 60 kg, n = 1400). During 12 months follow-up, we recorded management (catheterizations/revascularizations), antiplatelet therapy, major adverse cardiovascular events (MACEs), bleeding events (BARC classification), and mortality. Catheterizations (86.4% vs. 93.4%; p = 0.001) and revascularizations (64.8% vs. 76.1%; p = 0.001) were significantly lower in the LBW group. At discharge, prescription of new P2Y12 inhibitors was also lower in LBW patients (24.4% vs. 3...Continue Reading

References

Aug 23, 2003·Journal of the American College of Cardiology·Barnaby C ReevesGianni D Angelini
Nov 6, 2007·The New England Journal of Medicine·Stephen D WiviottUNKNOWN TRITON-TIMI 38 Investigators
May 23, 2009·Journal of the American College of Cardiology·Carl J LavieHector O Ventura
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Jan 7, 2010·British Journal of Pharmacology·Jolanta M Siller-MatulaBernd Jilma
Jan 29, 2010·European Heart Journal·Maarten L Simoons, Stephan Windecker
Feb 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kengo TsukaharaSatoshi Umemura
Aug 31, 2010·European Heart Journal·UNKNOWN Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for CardDavid Taggart
Sep 3, 2011·Cardiovascular Therapeutics·Joseph A JakubowskiDavid Erlinge
Apr 10, 2012·The American Journal of Medicine·Emily M BucholzHarlan M Krumholz
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·D CapodannoD J Angiolillo
Aug 2, 2013·Diabetes Care·Vojtech Hainer, Irena Aldhoon-Hainerová
Nov 14, 2013·Journal of the American Pharmacists Association : JAPhA
Feb 18, 2014·Journal of the American College of Cardiology·Carl J LavieSteven N Blair
Apr 25, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Shigeru SaitoMasato Nakamura
Oct 31, 2014·European Journal of Epidemiology·Jacek NiedzielaPiotr Rozentryt
Feb 14, 2015·Circulation·Alexander KulikUNKNOWN American Heart Association Council on Cardiovascular Surgery and Anesthesia
Jan 31, 2016·Progress in Cardiovascular Diseases·Carl J LavieRichard V Milani

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BETA
coronary artery bypass

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