PMID: 8949697Sep 1, 1996Paper

Low bone mineral density in small for gestational age infants: correlation with cord blood zinc concentrations

Archives of Disease in Childhood. Fetal and Neonatal Edition
F Chunga VegaC Coronel Rodriguez

Abstract

Twenty eight term small for gestational age (SGA) infants and 18 term appropriate for gestational age (AGA) infants were studied prospectively to assess bone mineral density and cord serum zinc concentrations. Growth and nutritional status were evaluated, and bone mineral density was measured by dual energy x ray densitometry of the lumbar spine. Cord serum zinc, parathyroid hormone, osteocalcin, vitamin D metabolite and mineral concentrations were measured. Growth, nutritional status, and bone mineral density (mean (SD) 0.223 (0.032) vs 0.277 (0.032) g hydroxyapatite/cm2) were significantly low in SGA infants. Bone mineral density was linearly related to growth and nutritional measures. Cord serum zinc concentrations were in the normal range and similar in both groups (mean (SD) 13.86 (3.0) vs 13.43 (2.1) mumol/l). It is suggested that SGA infants may not be zinc deficient. Low bone mineral density could be caused by growth and nutritional status deficiencies, the mechanisms for which could be those that reduce nutrient substrate supply to the fetus.

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Citations

Jun 15, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·M ChenJ D Carver
Aug 22, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·S KurlE Länsimies
May 29, 2000·The Proceedings of the Nutrition Society·R Namgung, R C Tsang
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Demetrios GourgiotisAriadne Malamitsi-Puchner
Nov 30, 2006·Annals of Tropical Paediatrics·Mustafa AkcakusSelmin Koklu
Dec 24, 1997·Acta Paediatrica. Supplement·A LapillonneB L Salle

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