Low brain oxygenation and differences in neuropsychological outcomes following severe pediatric TBI

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
L E Schrieff-ElsonAnthony A Figaji

Abstract

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children. Preventing secondary injury by controlling physiological parameters (e.g. intracranial pressure [ICP], cerebral perfusion pressure [CPP] and brain tissue oxygen [PbtO2]) has a potential to improve outcome. Low PbtO2 is independently associated with poor clinical outcomes in both adults and children. However, no studies have investigated associations between low PbtO2 and neuropsychological and behavioural outcomes following severe pediatric TBI (pTBI). We used a quasi-experimental case-control design to investigate these relationships. A sample of 11 TBI patients with a Glasgow Coma Scale score ≤8 who had PbtO2 and ICP monitoring at the Red Cross War Memorial Children's Hospital underwent neuropsychological evaluation ≥1 year post-injury. Their performance was compared to that of 11 demographically matched healthy controls. We then assigned each TBI participant into one of two subgroups, (1) children who had experienced at least one episode of PbtO2 ≤ 10 mmHg or (2) children for whom PbtO2 > 10 mmHg throughout the monitoring period, and compared their results on neuropsychological evaluation. TBI participants performed significantly more poo...Continue Reading

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Citations

Jan 13, 2018·Frontiers in Neuroanatomy·Aimee K DollmanLeigh E Schrieff-Elson
Sep 25, 2017·Current Opinion in Neurology·Alicia K Au, Robert S B Clark
Jul 5, 2017·Frontiers in Neurology·Carl-Henrik NordströmMagnus Olivecrona
Nov 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Heidi GriffithsJose A Pineda
Mar 4, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·A P RegensburgerF B Fahlbusch
Jun 10, 2021·Journal of Autism and Developmental Disorders·Jessica E RingshawSusan Malcolm-Smith
Sep 15, 2021·World Neurosurgery·Gideon AdegboyegaAndrew Folusho Alalade
Nov 27, 2021·Journal of the International Neuropsychological Society : JINS·Carly A CermakDeryk S Beal

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