Low calcium diet enhances development of hypertension in the spontaneously hypertensive rat

Clinical and Experimental Hypertension. Part A, Theory and Practice
R SchleifferA Gairard

Abstract

Young (5 week old) spontaneously hypertensive rats (SHR) were fed diets modified with respect to their calcium content. Control rats were given a normal calcium diet (0.3 per cent). During the experiment the systolic blood pressure (SBP), heart rate and serum level of total and ionized calcium were measured. Three diets were studied :calcium-free diet (0 per cent, h1), low calcium diet (0.03 per cent, h2) and high calcium diet (1.2 per cent, H). The h1 diet induced a transitory increase (at week 2), then a long-lasting decrease in SBP for 12 weeks. Heart rate and calcemia were significantly decreased. The h2 diet enhanced the increase in SBP and lowered heart rate for 10 weeks. Level of total and ionized serum calcium were unchanged. The high calcium diet (1.2 per cent) attenuated the increase in SBP for 44 weeks and enhanced the heart rate for 16 weeks. The serum level of total calcium remained stable but that of ionized calcium increased significantly at week 7. These data clearly establish that, in young SHR, a low calcium diet enhances the development of genetic hypertension and confirm earlier works obtained with calcium enriched diets. Experimental and clinical data lead us to emphasize the importance of alimentary calciu...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P NoonR J Baldessarini
Dec 1, 1979·Metabolism: Clinical and Experimental·S Ayachi
Sep 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·J P AldredJ W Bastian
Dec 1, 1974·Journal of Applied Physiology·Y ItokawaM Fujiwara
Dec 1, 1974·The Journal of Clinical Investigation·T A KotchenW Flamenbaum
Feb 15, 1982·Life Sciences·D A McCarron
Dec 1, 1980·Canadian Journal of Physiology and Pharmacology·G L WrightW Crouse
May 1, 1981·Hypertension·D A McCarronS Krutzik
Sep 15, 1981·American Journal of Obstetrics and Gynecology·J M BelizánJ Villar
Nov 1, 1981·Japanese Circulation Journal·R SchleifferA Gairard

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Citations

Nov 1, 1991·Biological Trace Element Research·N Krari, P Allain
Jan 1, 1986·Physiology & Behavior·F Ferrell, A Z Dreith
Nov 1, 1994·Physiology & Behavior·J L Rose, R McCarty
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·E I MangiaruaW D McCumbee
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·I PörstiH Vapaatalo
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·Y KageyamaT Saruta
Jun 1, 1992·International Journal of Cardiology·R Schleiffer
Oct 1, 1988·American Journal of Health Promotion : AJHP·C L MelbyG C Hyner
Nov 1, 1986·Hypertension·E T ZawadaD E McClung
Feb 1, 1990·Hypertension·R Di NicolantonioT O Morgan
Sep 1, 1985·Hypertension·K Lau, B Eby
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M R Jones, A Huibonhoa

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