PMID: 709092Sep 23, 1978Paper

Low-cholesterol diet: enhancement of effect of CDCA in patients with gall stones

British Medical Journal
D P MaudgalT C Northfield

Abstract

Fifteen patients with gall stones who were taking chenodeoxycholic acid(CDCA) 15 mg/kg at bedtime participated in two separate experiments to investigate the effects of altering sterol intake on the cholesterol saturation index (SI) of fasting gall-bladder bile. In experiment I the 15 patients on an unrestricted diet had a SI of 0.87 +/- 0.04 (mean +/- SE of mean), which fell to 0.75 +/- 0.04 after one week in hospital on a diet of 100 mg cholesterol daily. In experiment II seven of the patients were given four different dietary regimens lasting one month each in random order as outpatients. On a diet of 600 mg of cholesterol daily the mean SI was 0.72 +/- 0.05, which fell to 0.67 +/- 0.05 when the patients were put on a 100 mg cholesterol diet. The addition of plant sterols (3 g daily) to both diets raised the mean SIs to 0.80 +/- 0.05 and 0.77 +/- 0.05 respectively. The percentage CDCA in bile was unaffected by alterations in the cholesterol and plant sterol intakes. We conclude that a low-cholesterol diet but not a high intake of plant sterols enhances the effect of CDCA in patients with gall stones.

Citations

Mar 17, 1980·Klinische Wochenschrift·H J WeisP Gilsdorf
Jul 1, 1980·Irish Journal of Medical Science·J M WaltersC F McCarthy
Feb 1, 1993·The British Journal of Surgery·D P O'Leary, A G Johnson
Jun 1, 1991·European Journal of Clinical Investigation·A Lanzini, T C Northfield
May 1, 1982·Postgraduate Medicine·T N Tangedahl, W D Carey
Feb 1, 1990·Alimentary Pharmacology & Therapeutics·A Lanzini, T C Northfield
Oct 1, 1979·Hospital Practice·L J Schoenfield
Feb 1, 1986·Drug Intelligence & Clinical Pharmacy·M A Abate

Related Concepts

Biliary Sludge
Bile Salts
Quenocol
Cholelithiasis
Epicholesterol
Cholesterol, Dietary
Phytosterols

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