Low concentration of exogenous carbon monoxide protects mammalian cells against proliferation induced by radiation-induced bystander effect

Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis
Liping TongWei Han

Abstract

Radiation-induced bystander effect (RIBE) has been proposed to have tight relationship with the irradiation-caused secondary cancers beyond the irradiation-treated area after radiotherapy. Our previous studies demonstrated a protective effect of low concentration carbon monoxide (CO) on the genotoxicity of RIBE after α-particle irradiation. In the present work, a significant inhibitory effect of low-dose exogenous CO, generated by tricarbonyldichlororuthenium (II) dimer [CO-releasing molecule (CORM-2)], on both RIBE-induced proliferation and chromosome aberration was observed. Further studies on the mechanism revealed that the transforming growth factor β1/nitric oxide (NO) signaling pathway, which mediated RIBE signaling transduction, could be modulated by CO involved in the protective effects. Considering the potential of exogenous CO in clinical applications and its protective effect on RIBE, the present work aims to provide a foundation for potential application of CO in radiotherapy.

References

Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H ZhouT K Hei
Dec 13, 2000·Mutation Research·M Fenech
Feb 9, 2002·Circulation Research·Roberto MotterliniColin J Green
Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Maria KonopackaJoanna Rzeszowska-Wolny
Nov 14, 2002·International Journal of Radiation Biology·C ShaoK Ando
Aug 12, 2003·Trends in Immunology·Leo E OtterbeinFritz H Bach
Sep 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chunlin ShaoKevin M Prise
Dec 23, 2004·Seminars in Cancer Biology·Franziska MichorMartin A Nowak
Mar 10, 2005·International Journal of Cancer. Journal International Du Cancer·Chunlin ShaoKevin M Prise
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hongning ZhouTom K Hei
Nov 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gediminas CepinskasRichard F Potter
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·Tom K HeiCharles R Geard
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mariateresa MancusoAnna Saran
Apr 21, 2009·Nature Reviews. Cancer·Kevin M Prise, Joe M O'Sullivan

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Citations

Aug 27, 2014·Drug and Chemical Toxicology·Mostafa Norizadeh Tazehkand, Mehmet Topaktas
Dec 5, 2015·Drug and Chemical Toxicology·Mostafa Norizadeh TazehkandMehmet Bertan Yilmaz
Mar 14, 2017·Oxidative Medicine and Cellular Longevity·Malamati KourtiJun Cai
Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Sharmi MukherjeeAnindita Chakraborty

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