Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant.

Chemical Research in Toxicology
Kelly M Wynalda, Robert C Murphy

Abstract

Ozone is a common environmental toxicant to which individuals are exposed to on a daily basis. While biochemical end points such as increased mortality, decrements in pulmonary function, and initiation of inflammatory processes are known, little is actually understood regarding the chemical mechanisms underlying changes in pulmonary health, especially for low concentrations of ozone. This study was undertaken to investigate ozone-induced oxidation of endogenous lipids that are potentially exposed to environmental ozone within lung, specifically focusing on plasmalogen glycerophospholipids present in pulmonary surfactant. Sensitive liquid chromatography-mass spectrometry methods were developed to follow oxidation of diacyl and plasmalogen phosphatidylethanolamine (PE) phospholipids and to identify and quantitate products generated by ozonolysis. Using a unilamellar vesicle system containing a 1:1 molar mixture of 1-O-octadec-1'-enyl-2-octadecenoyl-PE and 1,2-dihexadecanoyl-PC, these studies revealed that the vinyl ether bond of plasmalogens was oxidized preferentially at low concentrations of ozone (100 ppb), when compared to olefinic bond oxidation on omega-9 of the fatty acyl chain in the same phospholipids. Major phospholipid...Continue Reading

References

Jan 1, 1991·American Journal of Respiratory Cell and Molecular Biology·R B DevlinH S Koren
Feb 1, 1988·Biomedical & Environmental Mass Spectrometry·J S HadleyR C Murphy
Sep 15, 1994·The Biochemical Journal·B RüstowP Stevens
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·G D ThurstonJ M Fine
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lidia MichalecSanjiv Sur
Sep 27, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M GuichardantM Lagarde
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Ichiro Kudo, Makoto Murakami
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Nov 25, 2003·International Journal of Hygiene and Environmental Health·Peter HöppeDennis Nowak
Jan 30, 2004·Biochemical Society Transactions·B Engelmann
Apr 21, 2004·The Journal of Biological Chemistry·Melissa K Pulfer, Robert C Murphy
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·Karin A Zemski Berry, Robert C Murphy
Dec 2, 2004·The European Respiratory Journal·R SchmidtA Günther
Jun 22, 2005·Toxicology and Applied Pharmacology·Alfred BernardClaire de Burbure
Apr 15, 2006·Journal of Lipid Research·Atsuyoshi NishinaShoei Furukawa
Jul 11, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M GuichardantM Lagarde
Mar 3, 2007·The Journal of Clinical Investigation·Edward M Postlethwait
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Courtney FraschDonna L Bratton
Apr 16, 2008·Infection and Immunity·Bryan P Hurley, Beth A McCormick
Aug 19, 2008·Environmental Health Perspectives·James S BrownWilliam F McDonnell
Sep 2, 2008·American Journal of Respiratory Cell and Molecular Biology·Benjamin D MedoffRamnik J Xavier
Sep 9, 2008·The Journal of Allergy and Clinical Immunology·Jonathan CiencewickiSteven R Kleeberger
May 19, 2009·American Journal of Respiratory and Critical Care Medicine·Edward S SchelegleRoblee P Allen
Jun 26, 2009·The New England Journal of Medicine·John L Semple, G W K Moore
Mar 27, 2010·Analytical Chemistry·Karin A Zemski BerryRobert C Murphy

❮ Previous
Next ❯

Citations

Oct 29, 2010·Environmental Health Perspectives·Urmila P KodavantiNarasimham L Parinandi
Mar 27, 2012·Journal of Clinical Biochemistry and Nutrition·Tetsuro IshiiToru Yanagawa
Jul 5, 2011·Chemistry and Physics of Lipids·Stefan Wallner, Gerd Schmitz
Mar 1, 2014·Photochemistry and Photobiology·Max T BourdillonRyan D McCulla
Feb 22, 2012·Biochimica Et Biophysica Acta·Ana Reis, Corinne M Spickett
Feb 23, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·WanYun ChengRobert B Devlin
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jennifer Strafford StevensKerry J Ressler
Jul 23, 2011·Journal of Applied Physiology·Stephanie NeuhausMarcus Peters
May 31, 2017·Harvard Review of Psychiatry·Margaret SpottswoodHsiang Huang
Jun 6, 2018·Journal of Addiction Medicine·Kara M BensleyEmily C Williams
May 6, 2017·Harvard Review of Psychiatry·Dawn E SugarmanShelly F Greenfield
Aug 28, 2019·Stress : the International Journal on the Biology of Stress·Tatiana S PoleschukSergey P Kasyanov
Nov 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pei-Yang GuQichun Zhang
Mar 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ernst R WernerKatrin Watschinger
Nov 29, 2011·The Analyst·Shane R EllisStephen J Blanksby
Mar 3, 2020·Frontiers in Medicine·Joanne E SordilloAnn Chen Wu
Oct 21, 2015·Angewandte Chemie·George N KhairallahRichard A J O'Hair
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Ruijiang ZhuoYuru Deng
Jan 31, 2018·Analytical Chemistry·Carlos GuijasGary Siuzdak
Jan 4, 2019·Chemical Research in Toxicology·Isaie SibomanaNicholas V Reo
May 26, 2012·Biochimica Et Biophysica Acta·Nancy E Braverman, Ann B Moser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.