PMID: 8614249Mar 10, 1995Paper

Low concentrations of nonsteroidal anti-inflammatory drugs affect cell functions

Life Sciences
M G SergeevaS D Varfolomeyev

Abstract

The effect of 10(-14)-10(-4)M ibuprofen and aspirin both on arachidonic acid metabolism in peritoneal murine macrophages and on the concanavalin A-induced proliferation of murine splenocytes were investigated. It was shown that 10(-7)-10(-4)M ibuprofen inhibits the arachidonic acid metabolism. On the other hand, 10(-12)-10(-11)M ibuprofen causes pronounced activation of arachidonic acid metabolism. The low concentration (10(-14)-10(-10)M) effects also take place when non-steroidal anti-inflammatory drugs influence other functions of the immune system: that is, they activate the splenocyte mitogen-induced proliferative response. These results are in accord with our suggestion that the low concentration effects of these drugs do not depend upon cell types and may have an important physiological significance.

References

Jul 29, 1976·Nature·D GordonJ Morley
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
Oct 1, 1991·Immunology Today·R P PhippsR L Roper

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Citations

May 5, 1999·Fundamental & Clinical Pharmacology·M BianchiA E Panerai
Sep 18, 1997·Medical Hypotheses·P BellaviteA Conforti
Oct 1, 1996·Applied Biochemistry and Biotechnology·M G SergeevaA T Mevkh

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