Low-conductance high selective inositol (1,4,5)-trisphosphate activated Ca2+ channels in plasma membrane of A431 carcinoma cells

FEBS Letters
Kirill KiselyovGalina N Mozhayeva

Abstract

In many cells, activation of receptors coupled to PIP2 turnover results in Ca2+ release from the intracellular stores accompanied by Ca2+ influx across the PM. It is not well established yet whether Ca2+ influx is activated by IP3 or by an unknown signal generated upon Ca2+ store depletion. We report here a single-channel study of low-conductance IP3-activated channels of very high selectivity for Ca2+ in the PM of A431 carcinoma cells. The channels are strongly potential dependent and sensitive to [Ca2+]i within the physiological range. The data obtained argues for IP3 acting directly on plasma membrane Ca2+ channels.

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Citations

Jul 16, 2003·European Journal of Pharmacology·Junko YoshidaMatomo Nishio
Jul 2, 2003·The Journal of General Physiology·Konstantin GusevGalina N Mozhayeva
Aug 24, 2011·The Journal of Heredity·Naïma BenbernouFrancis Galibert
Jul 6, 2011·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·A V ShalyginE V Kaznacheyeva
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·E KaznacheyevaG N Mozhayeva
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·K Mikoshiba, M Hattori
Mar 3, 2005·The Journal of Biological Chemistry·Vladislav BugajGalina N Mozhayeva
Jul 27, 2000·Anesthesia and Analgesia·A Kudoh, A Matsuki
Dec 17, 2004·Pharmacological Reviews·Régent LaporteIsmail Laher
Sep 3, 1999·The Journal of Biological Chemistry·A I ZubovG N Mozhayeva
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P Kaspler, M Horowitz
Dec 24, 2014·The Journal of Biological Chemistry·Alexey ShalyginElena Kaznacheyeva
Sep 24, 1999·Neuroscience and Behavioral Physiology·S B SemenovaG N Mozhaeva
Jun 7, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Akihiko Tanimura, Yosuke Tojyo
Oct 12, 2010·Cell Calcium·Alexey ShalyginElena Kaznacheyeva

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