Low cord blood pneumococcal immunoglobulin G (IgG) antibodies predict early onset acute otitis media in infancy

American Journal of Epidemiology
J C SalazarC T Le

Abstract

Low maternally derived serum immunoglobulin G (IgG) antibodies to Streptococcus pneumoniae capsular polysaccharides (PS) combined with the inability of infants to produce anti-PS antibody may explain onset of otitis media in the first 6 months of life. To explore this relation, cord blood samples were assayed for anti-PS IgG antibodies from 414 of 592 infants enrolled in a study of early onset otitis media between 1991 and 1994. Infants' ears were examined at health supervision and illness visits for the first 6 months of life in a large Minneapolis-St. Paul, Minnesota, health maintenance organization. Antibodies to seven common pneumococcal serotypes (3, 4, 6B, 14, 18C, 19F, and 23F) were measured by enzyme-linked immunoabsorbent assay (ELISA). Cox's regression analysis revealed that among infants with a sibling otitis media history, those with low concentrations of type 14 or 19F anti-PS cord blood antibody had earlier otitis media onset than those with higher cord blood antibody concentrations (relative risks (RR) (95% confidence intervals (CI)) = 1.77 (1.05-2.99) and 1.89 (1.11-3.23), respectively). Day care attendance also increased risk (RR = 1.56, 95% CI 0.96-2.52). Breastfeeding, parental smoking, and low anti-PS antibo...Continue Reading

Citations

Dec 12, 2001·Primary Care·W P Glezen
Feb 13, 2001·Vaccine·G S Giebink
May 20, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G S Giebink
Sep 3, 1998·The Pediatric Infectious Disease Journal·E M Eisenstein, B Gesundheit
Feb 29, 2000·The Pediatric Infectious Disease Journal·R A DamoiseauxG T Rijkers
May 23, 2000·The Pediatric Infectious Disease Journal·K A Daly, G S Giebink
Jun 24, 2003·Statistics in Medicine·Chap T LeG Scott Giebink
Apr 24, 2002·The Annals of Otology, Rhinology & Laryngology. Supplement·Kathleen A DalyPaul B van Cauwenberge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.