PMID: 11325421Apr 28, 2001Paper

Low-degree oxidized scleroglucan and its hydrogel

International Journal of Biological Macromolecules
H MaedaK Kajiwara

Abstract

A controlled oxidation of scleroglucan was performed with sodium periodate to prepare aldehyde derivatives (scleraldehyde) with a low degree of oxidation (10 and 20%), which were utilized for crosslinking reactions with hexamethylenediamine. The structural characterization of scleraldehydes and their corresponding hydrogels was attempted by small-angle X-ray scattering (SAXS). While scleraldehyde with a higher degree of oxidation (> or = 50%), according to an earlier research, was found to disentangle into single chains as the degree of oxidation increases; scleroglucan bearing a low percentage of aldehydic groups (up to 20%) retains mainly the conformation of the natural polysaccharide, thus the system can be represented as composed of triple helices with only minor disentanglements at the sites where the aldehyde groups are present. The hydrogel prepared from scleraldehyde with a low degree of oxidation is brittle and fragmented, in contrast to the elastic/homogeneous hydrogel earlier prepared from scleraldehyde with a high degree of oxidation. The hydrogel from scleraldehyde with a low degree of oxidation was found to possess a network structure that consisted mostly of the triple helices crosslinked in specific points where...Continue Reading

References

Oct 31, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·T CovielloF Alhaique

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Citations

Feb 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tommasina CovielloMario Grassi
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tommasina CovielloFranco Alhaique
Mar 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siddique Akber AnsariTommasina Coviello
Jun 5, 2018·The Journal of Physical Chemistry. B·Kazuto YoshibaBjørn E Christensen
Dec 4, 2012·Biomacromolecules·P RoblinA Buleon

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