Low-density lipoprotein-apolipoprotein B metabolism following apheresis: simulation studies of mass changes and tracer kinetics

Metabolism: Clinical and Experimental
P Hugh R Barrett, K G Parhofer

Abstract

Low-density lipoprotein (LDL) apheresis is an effective method to treat severe hyperlipoproteinemia such as heterozygous familial hypercholesterolemia (FH). It is unknown whether apheresis induces changes in metabolic parameters of LDL-apolipoprotein B (apoB) such as the fractional catabolic rate (FCR) or production rate. We performed simulation studies to determine the effect of potential changes in the LDL FCR on LDL-apoB mass and on exogenous and endogenous tracer studies. For these studies, we assumed a two-compartment LDL model and the following metabolic parameters: plasma LDL-apoB, 180 mg.dL(-1); LDL-apoB production rate, 36 mg.dL(-1).d(-1) (approximately 14.4 mg.kg(-1).d(-1)); and LDL-apo FCR, 0.2 d(-1). It was also assumed that apheresis instantaneously decreased the LDL-apoB concentration to 60 mg.dL(-1) and that LDL-apoB production was not perturbed. The simulations examined three possible outcomes: (1) no change in FCR, (2) a temporary doubling in FCR, and (3) a temporary tripling in FCR. Monoexponential models were fit to the rebound of LDL-apoB mass data generated using the different FCRs. In no instance did the FCR determined from the fit match the FCR used to generate the data; FCRs were either higher or lower t...Continue Reading

References

Aug 1, 1986·Metabolism: Clinical and Experimental·D M FosterJ D Brunzell
Dec 1, 1984·The Journal of Clinical Investigation·J ShepherdH G Morgan
Jun 1, 1995·Current Opinion in Lipidology·T D Watson

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Citations

Aug 12, 1999·Lipids·K G ParhoferP Schwandt
May 2, 2019·Current Atherosclerosis Reports·Gilbert Thompson, Klaus G Parhofer
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·C MaugeaisM Krempf

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