Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study

Lipids in Health and Disease
Michel R HoenigAllan Coulthard

Abstract

Visceral Fat Area (VFA) is an independent predictor of coronary disease. While low density lipoprotein cholesterol (LDL-C) is used to determine risk and guide therapy, its accuracy fails in obese patients who may have low LDL-C despite high VFA. We sought to describe the relationship between VFA, LDL-C and to describe shifting cholesterol metabolism with increasing VFA. 42 High-risk vascular patients not on lipid-lowering therapy provided a fasting lipid profile and underwent magnetic resonance imaging (MRI) to quantify VFA and subcutaneous fat area (SFA) at the L4-L5 disc. Comparisons: 1. Correlation between VFA, SFA, LDL-C and the standard lipid panel 2. Correlation between VFA, SFA and markers of cholesterol synthesis (desmosterol, lathosterol) and cholesterol absorption (cholestanol, sitosterol). VFA was inversely correlated with LDL-C (r = -0.348) indicating potential discordance between cardiovascular risk and LDL-C. However, VFA was appropriately correlated with other markers of increased risk: r = -0.361 with HDL-C, r = 0.503 with VLDL-C, r = 0.499 with TG (all p < 0.05). VFA did not correlate significantly with non-HDL-C. VFA correlated positively with cholesterol synthesis markers (desmosterol, lathosterol) and negati...Continue Reading

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Citations

Apr 19, 2012·Current Opinion in Lipidology·Dylan S MacKay, Peter J H Jones
Dec 29, 2011·Experimental Diabetes Research·Guenther SilbernagelAndreas Fritsche
Sep 20, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rida RashidNousheen Zaidi
Jul 20, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Giovanni TarantinoMarco Gentile
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Mar 7, 2018·Nature Genetics·Thomas J HoffmannNeil Risch
Jul 3, 2019·Biology of Sex Differences·Jessica L Faulkner, Eric J Belin de Chantemèle

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