Abstract
Visceral Fat Area (VFA) is an independent predictor of coronary disease. While low density lipoprotein cholesterol (LDL-C) is used to determine risk and guide therapy, its accuracy fails in obese patients who may have low LDL-C despite high VFA. We sought to describe the relationship between VFA, LDL-C and to describe shifting cholesterol metabolism with increasing VFA. 42 High-risk vascular patients not on lipid-lowering therapy provided a fasting lipid profile and underwent magnetic resonance imaging (MRI) to quantify VFA and subcutaneous fat area (SFA) at the L4-L5 disc. Comparisons: 1. Correlation between VFA, SFA, LDL-C and the standard lipid panel 2. Correlation between VFA, SFA and markers of cholesterol synthesis (desmosterol, lathosterol) and cholesterol absorption (cholestanol, sitosterol). VFA was inversely correlated with LDL-C (r = -0.348) indicating potential discordance between cardiovascular risk and LDL-C. However, VFA was appropriately correlated with other markers of increased risk: r = -0.361 with HDL-C, r = 0.503 with VLDL-C, r = 0.499 with TG (all p < 0.05). VFA did not correlate significantly with non-HDL-C. VFA correlated positively with cholesterol synthesis markers (desmosterol, lathosterol) and negati...Continue Reading
References
Feb 1, 1989·Metabolism: Clinical and Experimental·T A MiettinenY A Kesäniemi
Sep 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·E N MeilahnK A Matthews
Feb 28, 1994·Archives of Internal Medicine·M A DenkeS M Grundy
May 10, 1993·Archives of Internal Medicine·M A DenkeS M Grundy
Nov 5, 1999·Diabetes Care·W Y FujimotoP W Wahl
Jan 5, 2002·Lancet·G WalldiusE Steiner
Dec 28, 2002·Diabetes·Delma J NievesSteven E Kahn
Mar 7, 2003·Lancet·A D SnidermanG Walldius
Jun 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A OnatV Sansoy
Jul 14, 2004·Circulation·Scott M GrundyUNKNOWN American Heart Association
Jan 14, 2005·Internal Medicine·Takashi MiyawakiNobuo Saito
Jul 27, 2005·Diabetes Care·Jian LiuScott M Grundy
Nov 8, 2005·Lancet·Salim YusufUNKNOWN INTERHEART Study Investigators
Feb 16, 2006·Journal of Internal Medicine·P J BarterK M S Williams
Mar 28, 2006·The American Journal of Cardiology·Annie C St-PierreBenoît Lamarche
Dec 1, 2006·The American Journal of Cardiology·Jian LiuScott M Grundy
Apr 20, 2007·Journal of Human Hypertension·P A SarafidisG L Bakris
Jun 20, 2007·Circulation·Caroline S FoxChristopher J O'Donnell
Sep 28, 2007·Endocrine, Metabolic & Immune Disorders Drug Targets·Michel R HoenigJohn J Atherton
Oct 25, 2007·American Journal of Physiology. Endocrinology and Metabolism·Ranganath MuniyappaMichael J Quon
Feb 15, 2008·Journal of Human Hypertension·A L M VlekUNKNOWN SMART study group
Jun 10, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Annemarie Mj WassinkUNKNOWN Smart Study Group
Jul 17, 2008·Vascular Health and Risk Management·Michel R Hoenig
Dec 17, 2008·American Heart Journal·Amit SachdevaGregg C Fonarow
Feb 19, 2009·Journal of Vascular Surgery·Anne L M VlekUNKNOWN SMART Study Group
Aug 25, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G BrevettiM Chiariello
Citations
Apr 19, 2012·Current Opinion in Lipidology·Dylan S MacKay, Peter J H Jones
Dec 29, 2011·Experimental Diabetes Research·Guenther SilbernagelAndreas Fritsche
Sep 20, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rida RashidNousheen Zaidi
May 23, 2015·European Journal of Nutrition·Maëva JégouIsabelle Louveau
Jul 20, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Giovanni TarantinoMarco Gentile
Mar 29, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dylan S MackayDieter Lütjohann
Mar 7, 2018·Nature Genetics·Thomas J HoffmannNeil Risch
Jul 3, 2019·Biology of Sex Differences·Jessica L Faulkner, Eric J Belin de Chantemèle
Feb 23, 2020·Nutrients·Maria PerissiouRemco Polman
Mar 2, 2021·Heliyon·Naparat SukkriangSuttida Sangpoom