Low-density lipoprotein cholesterol response after statin initiation among persons living with human immunodeficiency virus

Journal of Clinical Lipidology
Greer A BurkholderRobert Rosenson

Abstract

Meta-analyses of general population studies report mean low-density lipoprotein cholesterol (LDL-C) reductions of 30% to <50% with moderate-intensity and ≥50% with high-intensity statins. Persons living with human immunodeficiency virus (PLWH) are at high risk for atherosclerotic cardiovascular disease (ASCVD), yet many have elevated LDL-C. To evaluate LDL-C response after statin initiation among PLWH. We conducted a retrospective cohort study of PLWH initiating statins between 2009 and 2013 (N = 706). Patients were categorized into mutually exclusive groups in the following hierarchy: history of coronary heart disease (CHD), diabetes, prestatin LDL-C ≥190 mg/dL, 10-year predicted ASCVD risk ≥7.5%, and none of the above (ie, unknown statin indication). The primary outcome was a ≥30% reduction in LDL-C after statin initiation. Among patients initiating statins, 5.8% had a history of CHD, 13.6% had diabetes, 6.2% had LDL-C ≥190 mg/dL, 35.4% had 10-year ASCVD risk ≥7.5%, and 39.0% had an unknown statin indication. Among patients with a history of CHD, 31.7% achieved a ≥30% LDL-C reduction compared with 25.0%, 59.1%, and 33.9% among those with diabetes, LDL-C ≥190 mg/dL, and 10-year ASCVD risk ≥7.5%, respectively. In multivariable ...Continue Reading

Citations

Feb 1, 2019·Circulation Research·Robert S RosensonWolfgang Koenig
Dec 28, 2019·Journal of the American Heart Association·Robert S RosensonLisandro D Colantonio
Sep 27, 2020·Cardiovascular Drugs and Therapy·Stephani C WangRobert S Rosenson
Jun 12, 2019·Nature Reviews. Cardiology·Priscilla Y Hsue, David D Waters
Apr 13, 2021·Current Opinion in HIV and AIDS·Matthew S Durstenfeld, Priscilla Y Hsue
Apr 3, 2020·Journal of the American College of Cardiology·Franck BoccaraUNKNOWN BEIJERINCK Investigators
Dec 12, 2021·European Journal of Preventive Cardiology·Benoît DelabaysJulien Vaucher

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