Abstract
Yolk represents the last growth stage of a single cell, the oocyte, which contains, besides bona fide cytoplasm, endocytosed serum-derived lipoproteins and minor components essential for normal embryo development. Transport of bulk lipoproteins, micronutrients, and morphogens to oocytes in parallel with maintenance of somatic homeostasis is achieved by ligand targeting via cell-specific expression of receptors and subtle differences in ligand structure. Lipoprotein metabolism is the prime example of these regulatory principles, in which receptors belonging to the low density lipoprotein receptor gene family play key roles. Here, we present the laying hen's features that make it an attractive model system to dissect macromolecular transport processes at the molecular level. In addition to the characterization of a family of yolk precursor receptors, studies on systemic vs. oocyte-directed transport have uncovered new aspects of the biological rationale for simultaneous expression of closely related genes in a single organism.
References
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S TakahashiT Yamamoto
Sep 1, 1991·The Journal of Nutrition·J Nimpf, W J Schneider
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S StifaniW J Schneider
Mar 24, 1995·The Journal of Biological Chemistry·L JacobsenJ Nimpf
Sep 8, 1993·Biochimica Et Biophysica Acta·A V Vieira, W J Schneider
Oct 6, 1995·The Journal of Biological Chemistry·H BujoW J Schneider
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·H BujoW J Schneider
Feb 17, 1995·The Journal of Biological Chemistry·A V VieiraW J Schneider
Sep 15, 1994·European Journal of Biochemistry·K OkaL Chan
Jan 1, 1994·Annual Review of Biochemistry·M Krieger, J Herz
Jul 1, 1994·Endocrinology·M E GåfvelsJ F Strauss
Mar 15, 1994·Genomics·K OkaL Chan
Apr 1, 1994·Human Molecular Genetics·J C WebbA K Soutar
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·F HoferD Blaas
Nov 1, 1993·Somatic Cell and Molecular Genetics·M E GåfvelsJ F Strauss
Sep 1, 1996·Poultry Science·H BujoW J Schneider
Citations
Mar 4, 1999·The Journal of Nutrition·R L WalzemR L Hamilton
Mar 4, 2003·The Journal of Nutrition·Mark P RichardsJohn P McMurtry
Mar 1, 2013·British Poultry Science·R P SinghJ S Tyagi
Aug 26, 2016·Genetics and Molecular Biology·ZhePeng WangYuPeng Gao
Aug 29, 2003·The Journal of Biological Chemistry·Yi ZhouMary Lou King
Jun 6, 2003·Endocrine Reviews·Attilio RigottiMonty Krieger
Oct 17, 2006·Journal of Evolutionary Biology·T RhenP Elf
Apr 15, 2011·British Poultry Science·S YalçınE Babacanoğlu
Mar 16, 2004·The Journal of Biological Chemistry·Susanna HummelWolfgang J Schneider
Nov 30, 2007·Proteomics·Karlheinz Mann, Matthias Mann
Oct 11, 2015·BMC Genomics·Hong LiXiaojun Liu
Mar 10, 2016·Avian Pathology : Journal of the W.V.P.A·Chia-Lan WangChung-Hsi Chou
Nov 23, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Shih Yi ChenKuo Lung Chen
Dec 6, 2001·The Journal of Clinical Investigation·H E MiettinenM Krieger
Jun 28, 2005·Parasitology·L Gomes Da SilvaM Dansa-Petretski
Oct 3, 2020·Gene·Guangyu LiuXiaolin Liu
Jan 6, 2007·The Journal of Biological Chemistry·Susanna HummelWolfgang J Schneider
May 1, 1997·The Journal of Nutrition·R G Elkin
Mar 29, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ju Hyeon KimJohn M Clark
Mar 1, 2020·Poultry Science·T NiiY Yoshimura
Apr 21, 2009·The Journal of Experimental Biology·Dong HanTony D Williams
May 29, 2003·Molecular and Cellular Endocrinology·N SatoT Tanaka