PMID: 11903833Mar 21, 2002Paper

Low-density lipoprotein subclasses in children under 10 years of age

Journal of Paediatrics and Child Health
K S SteinbeckL A Baur

Abstract

To examine the prevalence of small dense low density lipoprotein (LDL) in a cohort of children under 10 years of age and to investigate the relationship to other biochemical variables and to measures of fatness. A preponderance of small dense LDL (pattern B), is associated with obesity, abdominal fat accumulation, insulin resistance and risk of heart disease in adults. LDL peak particle diameter (PPD) was determined by gel electrophoresis in 53 children under 10 years of age and in 65 of their parents: apoproteins A1 and B were determined by turbidimetry. Anthropometric variables, basic lipid profiles, insulin and leptin had been determined previously. Differences between patterns A (large light particles > 25.5 nm diameter) and B were examined by t-test, Chi-square, or Mann-Whitney test. Relationships between the variables were reported as Pearson correlation coefficients. Pattern B (PPD of < or = 25.5 nm) prevalence was 7.5% in children and 11% in parents (17% in men and 5% in women). Most of the children (86%) who had PPD < or = 26.0 nm also had parents with PPD in this range. A strong association was found between children's and mother's PPD (r=0.60, P < 0.001), but this was somewhat less with fathers (r=0.40, P=0.02). Chil...Continue Reading

Citations

Mar 28, 2007·European Journal of Nutrition·Ramón CañeteAngel Gil
Oct 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Stephen F Burns, Silva A Arslanian
Apr 9, 2008·Journal of Atherosclerosis and Thrombosis·Roderick F G J KingPaul J Gately
Nov 10, 2005·European Journal of Clinical Nutrition·M MiyashitaK Harada

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