Low-dose aspirin and preterm birth: a randomized controlled trial

Obstetrics and Gynecology
Robert M SilverEnrique F Schisterman

Abstract

To evaluate the association between low-dose aspirin initiated before conception and the risk of preterm birth. This was a secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial. Women with a history of pregnancy loss (original stratum: one loss less than 20 weeks of gestation during the previous year; expanded stratum: one or two losses with no restrictions on timing or gestational age of the losses) were randomized to either daily low-dose aspirin (81 mg, n=615) and folic acid or folic acid alone (placebo; n=613). Preterm birth was compared between groups using intent-to-treat analysis. Preterm birth rates were 4.1% (22/535 low-dose aspirin) and 5.7% (31/543 placebo) (relative risk [RR] 0.72, 95% confidence interval [CI] 0.42-1.23); spontaneous preterm birth rates were 1.1% (6/535 low-dose aspirin) and 2.2% (12/543 placebo) (RR 0.51, 95% CI 0.19-1.34); medically indicated preterm birth rates were 2.6% (14/535 low-dose aspirin) and 2.9% (16/543 placebo) (RR 0.89, 95% CI 0.44-1.80). After restriction to confirmed pregnancies using inverse probability weighting, preterm birth rates were 5.7% and 9.0% (RR 0.63, 95% CI 0.37-1.09) and spontaneous preterm birth rates were 1.4% and 3.2% (RR 0.44, 95% CI 0.17...Continue Reading

Associated Clinical Trials

Apr 30, 2007·Enrique Schisterman, Enrique Schisterman

References

Feb 1, 1996·Obstetrics and Gynecology·G R AlexanderM Kogan
Jul 31, 1998·The New England Journal of Medicine·R L Goldenberg, D J Rouse
Jan 18, 2002·The New England Journal of Medicine·Marie C McCormick, Douglas K Richardson
Dec 18, 2003·Journal of the National Cancer Institute
Dec 23, 2009·Pediatrics·Stéphane MarretUNKNOWN EPIPAGE Study Group
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·David A MacIntyrePhillip R Bennett
Mar 1, 2012·Obstetrics and Gynecology Clinics of North America·Adi AbramoviciSheri M Jenkins
Jan 31, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S RobergeE Bujold

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Citations

Feb 19, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·A A AllshouseK D Heyborne
Dec 19, 2018·Canadian Journal of Physiology and Pharmacology·Lindsay D LevineEnrique F Schisterman
Mar 10, 2016·Obstetrics and Gynecology·Katherine A AhrensEnrique F Schisterman
May 31, 2019·Evidence-based Nursing·Anadeijda J E M C Landman, Martijn A Oudijk
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Lelia DuleyLisa M Askie
Jun 12, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Aswathi JayaramJames N Martin
Aug 7, 2017·F1000Research·Jeff A Keelan, John P Newnham
Apr 26, 2016·American Journal of Reproductive Immunology : AJRI·Paola TriggianeseRoberto Perricone
Sep 9, 2019·American Journal of Obstetrics and Gynecology·Piya ChaemsaithongLiona C Poon
Mar 12, 2021·Geburtshilfe und Frauenheilkunde·Richard BergerHolger Maul
Mar 23, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·A Brentisci, P Delorme
Jun 5, 2021·AJOG Global Reports·Vanessa L ShortRichard J Derman
May 10, 2018·Delaware Journal of Public Health·Matthew K Hoffman

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