Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice

Neurology
Lucía Cea SorianoL A García Rodríguez

Abstract

To quantify the risk of intracranial bleeds (ICBs) associated with new use of prophylactic low-dose aspirin using a population-based primary care database in the United Kingdom. A cohort of new users of low-dose aspirin (75-300 mg; n = 199,079) aged 40-84 years and a 1:1 matched cohort of nonusers of low-dose aspirin at baseline were followed (maximum 14 years, median 5.4 years) to identify incident cases of ICB, with validation by manual review of patient records or linkage to hospitalization data. Using 10,000 frequency-matched controls, adjusted rate ratios (RRs) with 95% confidence intervals (CIs) were calculated for current low-dose aspirin use (0-7 days before the index date [ICB date for cases, random date for controls]); reference group was never used. There were 1,611 cases of ICB (n = 743 for intracerebral hemorrhage [ICH], n = 483 for subdural hematoma [SDH], and n = 385 for subarachnoid hemorrhage [SAH]). RRs (95% CI) were 0.98 (0.84-1.13) for all ICB, 0.98 (0.80-1.20) for ICH, 1.23 (0.95-1.59) for SDH, and 0.77 (0.58-1.01) for SAH. No duration of use or dose-response association was apparent. RRs (95% CI) for ≥1 year of low-dose aspirin use were 0.90 (0.72-1.13) for ICH, 1.20 (0.91-1.57) for SDH, and 0.69 (0.50-0.9...Continue Reading

References

Dec 1, 1993·International Journal of Epidemiology·N Pearce
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Oct 27, 2006·Pharmacoepidemiology and Drug Safety·James D LewisBrian L Strom
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·David M HasanUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Dec 12, 2012·Pharmacoepidemiology and Drug Safety·David GaistLuis Alberto García-Rodríguez
Apr 4, 2013·World Neurosurgery·Bradley A GrossRose Du
Jul 12, 2013·Neurology·Luis A García-RodríguezAntonio González-Pérez
Jul 19, 2014·Journal of the American College of Cardiology·Sigrun HalvorsenRaffaele De Caterina
May 15, 2015·Cerebrovascular Diseases·Robert M StarkeDavid M Hasan
Jul 24, 2015·Thrombosis and Haemostasis·Anton PottegårdDavid Gaist
Dec 15, 2015·Pharmacoepidemiology and Drug Safety·Lucía Cea SorianoLuis A García Rodríguez
Apr 12, 2016·Annals of Internal Medicine·Kirsten Bibbins-Domingo, UNKNOWN U.S. Preventive Services Task Force
Mar 1, 2017·JAMA : the Journal of the American Medical Association·David GaistAnton Pottegård

❮ Previous
Next ❯

Citations

Jul 19, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Mervyn DI VergouwenNima Etminan
Oct 27, 2017·Stroke; a Journal of Cerebral Circulation·David GaistLuis Alberto García Rodríguez
Dec 6, 2018·Current Opinion in Neurology·Gabriel J E Rinkel
Feb 8, 2018·Current Neurology and Neuroscience Reports·Elif GokcalM Edip Gurol
Apr 25, 2020·International Journal of Cancer. Journal International Du Cancer·Luis A García RodríguezLucía Cea Soriano
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Katharina A M HackenbergNima Etminan
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Maximilian I SprügelHagen B Huttner
May 4, 2018·MMW Fortschritte der Medizin·S Evers
May 26, 2020·Deutsches Ärzteblatt International·Nima EtminanHelmuth Steinmetz
Apr 1, 2021·Journal of Neurointerventional Surgery·Stefan WandererSerge Marbacher
Mar 12, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Frederick EwbankDiederik Bulters
Jan 10, 2020·Journal of the American Medical Directors Association·Laura FanningIan C K Wong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.