PMID: 11343821May 10, 2001Paper

Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain

Neuroscience Letters
C J LaBuda, Perry N Fuchs

Abstract

The present experiment examined the effect of aspirin on the escape/avoidance behavioral response to a mechanical stimulus (476 mN von Frey monofilament) in the place escape avoidance paradigm (PEAP) following subcutaneous administration of carrageenan (CARR). Forty-one male Sprague-Dawley rats received subcutaneous injection of CARR or saline in the left hindpaw and 3 1/2 h later were administered aspirin (0, 50 or 150 mg/kg). Thirty minutes later, animals were tested in the PEAP and then the mechanical paw withdrawal threshold was measured. Compared with Saline vehicle-treated controls, all CARR-treated animals displayed hyperalgesia, as reflected by enhanced responding to mechanical stimulation applied to the CARR-injected paw. Mechanical hyperalgesia was significantly reduced by the pre-treatment of 150 mg/kg, but not 50 mg/kg aspirin. In the PEAP, CARR vehicle-treated animals avoided a preferred location of the test chamber that was associated with mechanical stimulation of the hyperalgesic paw. The shift from a preferred dark side of the chamber to the light side was attenuated by pre-treatment with both doses of aspirin (50 and 150 mg/kg). The lack of anti-hyperalgesia and avoidance behavior with 50 mg/kg aspirin suggest...Continue Reading

References

Sep 1, 1986·The Journal of Physiology·S M Hilton, W S Redfern
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Feb 12, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M L BlivenI G Otterness
Oct 17, 1998·Cancer Investigation·E Bruera
Nov 25, 2000·Alcohol·C J LaBuda, P N Fuchs

❮ Previous
Next ❯

Citations

Jan 29, 2011·Neuroscience Bulletin·Xu-Jie ZhangHui Xu
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Jeremy W SmithJames W Smythe
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jul 17, 2004·Neuroreport·Christopher J LaBuda, Ted B Usdin
Aug 26, 2009·Neuropharmacology·Janel M Boyce-RustayPrisca Honore
Mar 19, 2013·Annals of the New York Academy of Sciences·Edita NavratilovaFrank Porreca
Feb 11, 2012·European Journal of Pain : EJP·Y ZhangR-X Zhang
Nov 13, 2010·Brain Research·Cathrine BaastrupNanna Brix Finnerup
May 16, 2014·Frontiers in Integrative Neuroscience·Perry N FuchsMegan L Uhelski
Sep 1, 2008·Expert Opinion on Drug Discovery·Daniel N CortrightDaniel C Broom
May 25, 2005·Journal of Neuroscience Methods·Christopher J LaBuda, Patrick J Little

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.