Low-dose aspirin improves in vivo hemodynamics in conscious, chronically infarcted rats

Cardiovascular Research
R G SchoemakerE A Kalkman

Abstract

The equivalent of the clinically used low (= antiplatelet)-dose aspirin, inhibited collagen deposition in the non-infarcted myocardium in rats with myocardial infarction. In the present study, the in vivo hemodynamic consequences of this daily low-dose aspirin were investigated in conscious, chronically instrumented, infarcted rats. Rats, treated with 25 mg/kg aspirin daily from 2 days before to 3 weeks after coronary artery ligation, were chronically instrumented with an electromagnetic flow-probe and arterial and venous catheters, to record cardiac output, and arterial and venous blood pressure, respectively, in the conscious freely moving animal. In parallel, isolated hearts were studied with regard to left ventricular stiffness (pressure/volume relationships), maximal cardiac perfusion (adenosine), and in vitro heart rate and beta-adrenergic responsiveness. Plasma catecholamine levels were measured. Aspirin normalized the increased heart rate after infarction, at a preserved cardiac output. This was accompanied by a (non-significant) increase in stroke volume, at unchanged cardiac loading conditions. The lower heart rate after aspirin was due to reduced intrinsic heart rate rather than to lower sympathetic activation of the...Continue Reading

Citations

Jun 3, 2000·Archives of Pharmacal Research·B C Cha, S B Lee
Jun 14, 2000·European Journal of Pharmacology·R Van KerckhovenR G Schoemaker
Aug 7, 2002·European Journal of Pharmacology·Roeland Van KerckhovenRegien G Schoemaker
May 4, 1999·European Journal of Pharmacology·E A KalkmanR G Schoemaker
Oct 21, 2000·Journal of Molecular and Cellular Cardiology·J W de JongC Ceconi
Nov 22, 2008·Ageing Research Reviews·Gus Q Zhang, Weiguo Zhang
May 18, 2016·Journal of Pharmaceutics·Archana VyasRameshwar Jatwa
Apr 21, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jianyong LiZhiqi Liu
Oct 22, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jianyong LiJiyu Zhang
Jan 9, 2009·Journal of Cardiovascular Pharmacology·Nadir UluWiek H van Gilst
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Elza D van DeelDirk J Duncker

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