PMID: 9163613May 1, 1997Paper

Low-dose aspirin in polycythaemia vera: a pilot study. Gruppo Italiano Studio Policitemia (GISP)

British Journal of Haematology

Abstract

In this pilot study, aimed at exploring the feasibility of a large-scale trial of low-dose aspirin in polycythaemia vera (PV), 112 PV patients (42 females, 70 males. aged 17-80 years) were selected for not having a clear indication for, or contraindication to, aspirin treatment and randomized to receive oral aspirin (40 mg/d) or placebo. Follow-up duration was 16 +/- 6 months. Measurements of thromboxane A2 production during whole blood clotting demonstrated complete inhibition of platelet cyclooxygenase activity in patients receiving aspirin. Aspirin administration was not associated with any bleeding complication. Within the limitations of the small sample size, this study indicates that a biochemically effective regimen of antiplatelet therapy is well tolerated in patients with polycythaemia vera and that a large-scale placebo-controlled trial is feasible.

Citations

Mar 20, 2010·Internal and Emergency Medicine·Raffaele LandolfiLeonardo Di Gennaro
May 23, 1998·Blood Reviews·S Willoughby, T C Pearson
Feb 14, 2002·British Journal of Haematology·Jerry L Spivak
Jan 9, 2004·The New England Journal of Medicine·Raffaele LandolfiUNKNOWN European Collaboration on Low-Dose Aspirin in Polycythemia Vera Investigators
May 18, 2011·JAAPA : Official Journal of the American Academy of Physician Assistants·Rami Khouzam, Mary Jane Gallahan
Jan 11, 2007·Orphanet Journal of Rare Diseases·Jean B Brière
Sep 13, 2000·Drugs & Aging·P J van Genderen, M M Troost
Aug 15, 2014·Current Hematologic Malignancy Reports·Alberto Alvarez-Larrán, Carlos Besses
Feb 9, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maurizio ZangariJosef T Prchal
Mar 23, 2002·Leukemia & Lymphoma·Ayalew Tefferi
Jul 13, 2002·Expert Review of Anticancer Therapy·Nathaniel I Berlin
Mar 9, 2013·Expert Review of Cardiovascular Therapy·Bianca RoccaFrancesca Pagliaccia
Apr 1, 2011·Gynécologie, obstétrique & fertilité·G GiraudetV Houfflin-Debarge
Jul 21, 2005·British Journal of Haematology·Mary F McMullinUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·A L FrelingerA D Michelson
Jan 20, 2000·Baillière's Clinical Haematology·A Tefferi, M N Silverstein
Jun 20, 2006·Best Practice & Research. Clinical Haematology·Tiziano Barbui, Guido Finazzi
Aug 25, 2015·Clinical Lymphoma, Myeloma & Leukemia·Lorenzo FalchiSrdan Verstovsek
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roberto MarchioliTiziano Barbui
Mar 14, 2007·Hematological Oncology·Mary Frances McMullin
May 2, 2013·The Cochrane Database of Systematic Reviews·Alessandro SquizzatoSaskia Middeldorp
Feb 1, 2007·Blood·Guido Finazzi, Tiziano Barbui
Nov 25, 2003·Hematology·Jerry L SpivakMonia Marchetti
Sep 24, 1999·The Medical Journal of Australia·M A BentleyS J Wright
May 3, 2001·Blood Reviews·D MateiV J Marder
Sep 12, 2021·Reviews in the Neurosciences·Marco BurattiniGiovanna Viticchi

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