Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.

Journal of Gastroenterology
Akiko ShiotaniKen Haruma

Abstract

Meta-analyses of randomized, placebo-controlled trials of low-dose aspirin indicate that aspirin approximately doubles the risk of major GI bleeding compared with placebo. The risk in Japanese may possibly be higher compared to Western populations, although the evidence is still lacking and prospective studies are required. Prior GI events, older age, and use of other injurious medicines such as NSAIDs, anticoagulants, and corticosteroids seem to be factors associated with an increased risk for upper GI bleeding among aspirin users. Prospective studies are needed to identify specific risk factors for upper GI bleeding in Japanese patients taking low-dose aspirin. There are many potential gastroprotective drugs available in Japan, and studies are needed to assess the relative effectiveness of various strategies including PPI use for the prevention of aspirin-related upper GI ulcer complications and whether any of these other agents also provide protection against small bowel or colonic damage. Aspirin-induced enteropathy is now increasingly being recognized and is presumably not uncommon, and the availability of new imaging techniques for the small intestine and noninvasive tests such as fecal calprotectin should allow rapid pro...Continue Reading

References

Sep 10, 1992·The New England Journal of Medicine·M C AllisonR I Russell
Oct 1, 1990·The British Journal of Surgery·R G WilsonI M Macintyre
Feb 1, 1990·Digestive Diseases and Sciences·F M GiardielloJ H Yardley
Jul 20, 1989·The New England Journal of Medicine·UNKNOWN Steering Committee of the Physicians' Health Study Research Group
Oct 1, 1987·Annals of Internal Medicine·H J Kaufmann, H L Taubin
Apr 1, 1995·BMJ : British Medical Journal·J WeilP Wainwright
Nov 1, 1993·Scandinavian Journal of Gastroenterology·D Y GrahamZ A Saeed
Mar 15, 2000·Circulation·E H Awtry, J Loscalzo
Jul 25, 2000·The Cochrane Database of Systematic Reviews·A RostomJ McGowan
Sep 28, 2000·The American Journal of Gastroenterology·H T SørensenJ H Olsen
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Jun 28, 2002·The New England Journal of Medicine·Kam Chuen LaiJohn Wong
Sep 27, 2002·The New England Journal of Medicine·Mette HurlenHarald Arnesen
Jan 10, 2003·The Cochrane Database of Systematic Reviews·A RostomJ McGowan

❮ Previous
Next ❯

Citations

Jul 14, 2010·Journal of Gastroenterology and Hepatology·Akiko ShiotaniKen Haruma
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Kenichi NonoyamaSusumu Okabe
Apr 18, 2012·Journal of Gastroenterology and Hepatology·Akiko ShiotaniKen Haruma
Jan 1, 2010·Drug, Healthcare and Patient Safety·Harald VonkemanMart van de Laar
Jul 21, 2012·World Journal of Gastrointestinal Endoscopy·Haruka FujinamiToshiro Sugiyama
Oct 13, 2011·ISRN Gastroenterology·A TimrazA Essaid
Feb 14, 2009·Journal of Gastroenterology·Akiko ShiotaniKen Haruma
May 19, 2009·Journal of Gastroenterology·Akiko ShiotaniKen Haruma
Jun 15, 2013·Digestive Diseases and Sciences·Hiroshi SatohKoji Takeuchi
Nov 18, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Akiko ShiotaniKen Haruma
Aug 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Randall W Lengeling, Konrad S Schulze
May 19, 2009·Gastroenterology Clinics of North America·Rupert W Leong
Feb 2, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Eiji SakaiAtsushi Nakajima
Sep 22, 2010·Journal of Clinical Pharmacy and Therapeutics·S I Al-AzzamY S Khader
Sep 26, 2013·Gastroenterology Research and Practice·Harunobu KawamuraAtsushi Nakajima
Nov 26, 2010·International Journal of Cardiology·Guillaume CaylaGilles Montalescot
Jun 1, 2012·Current Therapeutic Research, Clinical and Experimental·Shino ShimuraYoshikazu Kinoshita
Sep 17, 2014·Nutrition Research Reviews·Maren Podszun, Jan Frank
Feb 28, 2016·Digestive Diseases and Sciences·Hiroshi Satoh, Tetsuro Urushidani
Oct 13, 2018·Journal of Hepato-biliary-pancreatic Sciences·Yusuke KawamotoAkira Tanaka
Nov 26, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jun Haeng LeeUNKNOWN Korean Association of Gastroenterology
Feb 11, 2010·Physical Chemistry Chemical Physics : PCCP·Katharina BicaRobin D Rogers
Dec 8, 2010·Scandinavian Journal of Gastroenterology·Akiko ShiotaniKen Haruma
Nov 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Yong Ahn
Jun 2, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yukiko HandaAkiko Shiotani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.