Low-dose aspirin inhibits platelet-induced contraction of the human isolated coronary artery. A role for additional 5-hydroxytryptamine receptor antagonism against coronary vasospasm?

Circulation
W A BaxP R Saxena

Abstract

The beneficial effect of low-dose aspirin in the prevention of coronary vasospasm is well documented. In this study, we investigated the contractile effect of human washed platelets on the human isolated coronary artery. We concentrated on the effect of low-dose aspirin (40 mg/d) taken by the platelet donor and on the efficacy of thromboxane A2 (TXA2) and 5-hydroxytryptamine (5-HT) receptor antagonists. Human coronary artery segments were suspended in an organ bath set-up for isometric tension measurement. Platelets (10(9) to 3 x 10(10)/L) elicited concentration-dependent contractile responses of the coronary artery segments, reaching 28.4 +/- 7.1% of contractions induced by 100 mmol/L K+. The contractile response tended to be decreased in vessel segments with histological signs of early atherosclerosis. Contraction was significantly attenuated after pretreatment of the vessel segments with ketanserin (5-HT2 receptor antagonist, 1 mumol/L) or SQ30741 (TXA2 receptor antagonist, 0.01 mumol/L), reaching 8.8 +/- 2.3% and 3.2 +/- 2.2% of contraction to 100 mmol/L K+, respectively. Platelets obtained from the same platelet donors after they had taken aspirin (40 mg/d for 7 to 13 days) caused significantly lower contractile responses ...Continue Reading

References

May 1, 1992·European Journal of Clinical Investigation·Freek J ZijlstraR C Jongejan
Oct 31, 1991·The New England Journal of Medicine·Dutch TIA Trial Study GroupAnet van Latum
Mar 7, 1991·The New England Journal of Medicine·L D Hillis, R A Lange
Jun 1, 1991·Trends in Pharmacological Sciences·P R Saxena, C M Villalón
Feb 14, 1989·European Journal of Pharmacology·H E ConnorP P Humphrey
Jul 20, 1989·The New England Journal of Medicine·Steering Committee of the Physicians' Health Study Research Group
Dec 1, 1985·Circulation·C PatronoL Forni
Mar 1, 1983·Biochemical Pharmacology·F De Clerck, J M Van Nueten
Jul 23, 1981·Nature·R J Haslam, M D McClenaghan

Citations

May 1, 1995·Pharmacology & Therapeutics·P R Saxena
Jul 9, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Seo Young ChoiJi-Soo Kim
Aug 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D FekkesL Pepplinkhuizen
Oct 29, 1998·Mediators of Inflammation·J D van BergeijkFreek J Zijlstra
Sep 23, 1997·Journal of Cardiovascular Pharmacology·Y IshibashiR J Bache
Nov 26, 1998·The British Journal of Ophthalmology·C W StorimansJ A Oosterhuis
Jan 12, 2013·Cardiovascular Diabetology·Theodor BaarsPetra Kleinbongard
May 24, 2008·Anesthesia and Analgesia·Feikje WesseldijkFreek J Zijlstra
Mar 29, 2000·The Annals of Thoracic Surgery·C I ChardignyT J Verbeuren
Jul 19, 2011·Journal of Molecular and Cellular Cardiology·Petra KleinbongardGerd Heusch
May 8, 1998·Toxicology and Applied Pharmacology·J Y LeeJ H Chung
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Petra KleinbongardGerd Heusch

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