Low dose BCG as adjuvant therapy for superficial bladder cancer and literature review

ANZ Journal of Surgery
C W ChengW H Sun

Abstract

Bacillus Calmette-Guerin (BCG) at low doses has long been employed as prophylactic and therapeutic treatment for superficial cancer of the urinary bladder, aiming at reducing toxicity while maintaining efficacy. A retrospective review was reported, together with a review of the literature with respect to a low dose BCG regimen. Forty-five consecutive patients with superficial bladder cancer (Ta or T1) with one or more of the appropriate criteria (grade above 1, stage above a, size >1 cm, multiple or recurrent), after complete transurethral resection, received 27 mg Connaught strain BCG weekly for 6 weeks. There was no maintenance therapy. Patients were evaluated with urine cytology and cystoscopy. Recurrence, progression and death were analysed. With a median follow up of 14 (range 3-61) months, 24 (53%) of the 45 patients responded to one course of 6 weekly BCG without recurrence. A further group of 13 (29%) patients responded to a second course of BCG on recurrence. Disease progressed in one (2.2%) patient. Two (4.4%) patients died of an unrelated condition. There was no disease specific mortality. Side-effects were common but well tolerated, with only two (4.4%) cases of treatment interruption. Low dose BCG could be an alter...Continue Reading

References

Nov 1, 1982·The Journal of Urology·D L LammR M Lucio
Jan 1, 1995·European Urology·F PaganoC Milani
Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H W HerrH F Oettgen
Mar 4, 2000·The Urologic Clinics of North America·G Dalbagni, H W Herr
Apr 23, 2002·BJU International·J A Martínez-PiñeiroUNKNOWN for CUETO (Club Urológico Español de Tratamiento Oncológico)

❮ Previous
Next ❯

Citations

Apr 26, 2007·Bulletin of Mathematical Biology·Svetlana Bunimovich-MendrazitskyLewi Stone
Aug 22, 2008·Bulletin of Mathematical Biology·Svetlana Bunimovich-MendrazitskyLewi Stone
Jun 3, 2011·Mathematical Biosciences and Engineering : MBE·Svetlana Bunimovich-Mendrazitsky, Yakov Goltser
Jan 1, 2008·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Rakesh KapoorPratipal Singh
Feb 22, 2011·Journal of Theoretical Biology·Svetlana Bunimovich-MendrazitskyJoel Chaskalovic
Oct 24, 2007·European Urology·Jesus Fernandez-GomezUNKNOWN Club Urológico Español de Tratamiento Oncológico (CUETO)
Jun 3, 2021·Vaccines·Fabíola CardilloRosa Teixeira Pinho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.