Low-dose Carbicarb improves cerebral outcome after asphyxial cardiac arrest in rats

Annals of Emergency Medicine
L M KatzThomas W Bouldin

Abstract

Controversy surrounds the use of buffers during cardiac arrest to correct acidosis. The objective of this study was to determine whether attenuation or neutralization of cerebral acidosis by Carbicarb alters hippocampal glutamate levels, neuronal cell death, and neurologic deficits after reperfusion from asphyxial cardiac arrest in rats. Rats were prospectively randomized to either a control (n=45), low-dose Carbicarb (LDC; 3 mL/kg, n=45), or high-dose Carbicarb (HDC; 6 mL/kg, n=45) group in a blinded fashion during resuscitation after 8 minutes of asphyxial cardiac arrest. Microdialysis was used to assess brain pH and glutamate. A neurologic deficit score and neuronal cell death in the hippocampus were determined at day 7. Resuscitation was greatest in LDC rats (42/45) and least in HDC rats (28/45) versus that in control rats (34/45). Brain pH was higher in the LDC and HDC rats 10 minutes after resuscitation and remained higher than that of control rats for 120 minutes after resuscitation. Glutamate levels at 10 to 120 minutes after reperfusion were lowest in the LDC rats. LDC rats had the lowest neurologic deficit score (1+/-2) versus that of control rats (13+/-8) and HDC rats (19+/-6). Hippocampal neuronal cell death was low...Continue Reading

Citations

Aug 3, 2012·Journal of Veterinary Emergency and Critical Care·Elizabeth A RozanskiUNKNOWN RECOVER Advanced Life Support Domain Worksheet Authors
Nov 5, 2013·Translational Stroke Research·Kunjan R DaveMiguel A Perez-Pinzon
Aug 8, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vélvá M CombsKelly L Drew
Feb 16, 2021·Frontiers in Veterinary Science·Daniel J Fletcher, Manuel Boller
Mar 9, 2021·Circulation·Cameron DezfulianUNKNOWN American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Arterioscl
Jan 5, 2011·Brain Research·Amy L UhernikJeffrey P Smith

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