Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma

International Immunopharmacology
Rie TabataTomoko Nagai

Abstract

Immune thrombocytopenic purpura associated with multiple myeloma is extremely rare. Here, we present the successful management of an elderly Japanese patient with multiple myeloma complicated by immune thrombocytopenia with low dose cepharanthine - a plant derived alkaloid. A 78-year-old male patient with IgGκ multiple myeloma was repetitively treated with melpharan and prednisolone. In each chemotherapy course, we demonstrated a close relationship between platelet recovery and administration of high dose prednisolone. When further chemotherapy was avoided because of the patient's poor general condition, administration of cepharanthine was effective in halting progressive thrombocytopenia due to abnormal immune mechanisms. We propose the usefulness of cepharanthine in management of this rare disease.

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Citations

Apr 29, 2014·Journal of Ethnopharmacology·Camille DesgrouasEvelyne Ollivier
May 15, 2016·Annals of Hematology·Eamonn FallerRonan Desmond
May 8, 2018·European Journal of Haematology·Mahmoud H Ayesh Haj YousefYousef Khader
Dec 26, 2015·The Journal of Biological Chemistry·Cheuk Wun LiYaron Tomer
Apr 11, 2018·Frontiers in Pharmacology·Chen-He ZhouHao-Bo Wu
May 28, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Christian Bailly

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