Low-dose computed tomography volumetry for subtyping chronic lung allograft dysfunction

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
T SaitoS Keshavjee

Abstract

The long-term success of lung transplantation is challenged by the development of chronic lung allograft dysfunction (CLAD) and its distinct subtypes of bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). However, the current diagnostic criteria for CLAD subtypes rely on total lung capacity (TLC), which is not always measured during routine post-transplant assessment. Our aim was to investigate the utility of low-dose 3-dimensional computed tomography (CT) lung volumetry for differentiating RAS from BOS. This study was a retrospective evaluation of 63 patients who had developed CLAD after bilateral lung or heart‒lung transplantation between 2006 and 2011, including 44 BOS and 19 RAS cases. Median post-transplant follow-up was 65 months in BOS and 27 months in RAS. The median interval between baseline and the disease-onset time-point for CT volumetry was 11 months in both BOS and RAS. Chronologic changes and diagnostic accuracy of CT lung volume (measured as percent of baseline) were investigated. RAS showed a significant decrease in CT lung volume at disease onset compared with baseline (mean 3,916 ml vs 3,055 ml when excluding opacities, p < 0.0001), whereas BOS showed no significant post-transpla...Continue Reading

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Citations

Oct 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H SuhlingJ Gottlieb
Dec 23, 2016·Clinical Transplantation·Cristina BerasteguiAntonio Román
Oct 19, 2017·General Thoracic and Cardiovascular Surgery·Toyofumi F Chen-Yoshikawa, Hiroshi Date
Jul 19, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robin VosGeert M Verleden
Mar 17, 2020·Journal of Computer Assisted Tomography·Mnahi Bin SaeedanSubha Ghosh
Jan 5, 2020·Insights Into Imaging·Mnahi Bin SaeedanRahul D Renapurkar
May 21, 2020·Medicina clínica·José A Cerón NavarroGabriel Sales Badía
Jan 9, 2020·Transplantation Proceedings·Hans Henrik Lawaetz SchultzMartin Iversen
May 6, 2021·Diagnostics·Anne-Laure BrunPhilippe A Grenier
Oct 12, 2021·Clinical Transplantation·Laura H PeräkyläAntti I Nykänen

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