PMID: 8600411Mar 1, 1996Paper

Low-dose cyclosporin A therapy in treating chronic, noninfectious uveitis

Ophthalmology
A T VitaleC Stephen Foster

Abstract

To describe the authors' approach to the management of patients with recalcitrant, chronic, endogenous uveitis using low-dose Cyclosporin A (CSA) alone or in combination with other immunosuppressive agents with attention to the anti-inflammatory efficacy, visual outcome, and side effects of therapy. The authors reviewed the records of 50 patients (92 eyes) with uveitis of various etiologies who had been treated with low-dose CSA (2.5-5.0 mg/kg daily) alone or in combination with prednisone and/or azathioprine (1.5-2.0 mg/kg daily). The median follow-up on low-dose CSA was 16 months (range, 6-64 months). Inflammatory control was achieved in 68 (73.9%) eyes, while persistent inflammatory activity was observed in 14 (15.2%). Thirty-eight (41%) eyes improved two Snellen lines or more, 43 (47.0%) stabilized, and 11 (12.0%) lost two lines or more. The CSA was discontinued because of nephrotoxicity in three patients and in each of two with systemic hypertension and constitutional intolerance to the drug, respectively. Thirteen patients enjoy inflammatory remission with this regimen. Low-dose CSA used alone or in combination with other immunosuppressive agents is effective in achieving inflammatory control with a favorable visual outco...Continue Reading

References

Jun 1, 1990·The British Journal of Ophthalmology·J de VriesA Kijlstra
May 15, 1986·The New England Journal of Medicine·A G PalestineR B Nussenblatt
Jun 1, 1984·American Journal of Ophthalmology·R B NussenblattR Caruso
Jan 1, 1993·Ocular Immunology and Inflammation·E CohenD Benezra

❮ Previous
Next ❯

Citations

Aug 24, 1999·Springer Seminars in Immunopathology·R N Van Gelder, H J Kaplan
Sep 16, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaoguang DongPing Lin
Mar 26, 2004·Transplantation Proceedings·D A HesselinkP M van Hagen
Sep 23, 2003·Survey of Ophthalmology·Kaisu KotaniemiKimmo Aho
Apr 25, 2001·Eye·G FreemanC E Pavesio
Nov 8, 2001·International Ophthalmology Clinics·N K WaheedC S Foster
Jun 14, 2006·International Ophthalmology Clinics·Eva Christina Kim, C Stephen Foster
Jun 9, 1998·Current Opinion in Nephrology and Hypertension·T F Andoh, W M Bennett
Jul 23, 2008·International Ophthalmology Clinics·Manfred ZierhutChristoph Deuter
Jan 30, 1999·The British Journal of Ophthalmology·F G RobergeJ Hakimi
Jan 30, 1999·The British Journal of Ophthalmology·D J KilmartinA D Dick
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J R Smith, J T Rosenbaum
Nov 12, 2003·Current Rheumatology Reports·Lucila M A AgleThomas J A Lehman
Feb 16, 2016·Progress in Retinal and Eye Research·Liping DuPeizeng Yang
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Lauren P Schewitz-BowersRichard W J Lee
Dec 25, 2009·Ophthalmology·R Oktay KaçmazC Stephen Foster
Feb 24, 2016·Clinics in Dermatology·Karolyn A WanatMisha Rosenbach
Jun 17, 2006·Best Practice & Research. Clinical Rheumatology·Santiago Muñoz-Fernández, Emilio Martín-Mola
Nov 29, 2014·Clinical Reviews in Allergy & Immunology·Sergio Schwartzman, Monica Schwartzman
Nov 3, 2005·Survey of Ophthalmology·Kayur H ShahGary N Holland
Sep 21, 2005·Ophthalmology·Howesen KokSusan Lightman
Oct 10, 2007·Expert Opinion on Investigational Drugs·Eddy AngladeUlrich Grau
Jul 23, 1999·Renal Failure·G A PorterW M Bennett
Dec 13, 2006·Ocular Immunology and Inflammation·Mamta AgarwalJyotirmay Biswas
Oct 25, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Zi YePeizeng Yang
Jul 27, 2010·Seminars in Arthritis and Rheumatism·Esperanza PatoUNKNOWN Uveitis Working Group from Spanish Society of Rheumatology
Feb 4, 2006·Drug Development and Industrial Pharmacy·Chen LiuYuanying Pei
Aug 22, 2008·Ocular Immunology and Inflammation·Patricio A PachecoGonzalo V Diaz
Apr 7, 2006·Ocular Immunology and Inflammation·I ParedesC S Foster
Mar 14, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wendy M Smith
Nov 17, 2017·Advances in Therapy·Ioannis AsproudisAnastasios G Konstas
Oct 17, 2017·Advanced Healthcare Materials·Michelle L RataySteven R Little
Jan 18, 2013·Ocular Immunology and Inflammation·Cheryl A ArcinueC Stephen Foster
Feb 22, 2001·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·B OrenJ Zobal-Ratner
Jan 16, 1999·Baillière's Clinical Rheumatology·H Dollfus
May 1, 2007·Ophthalmology·Aideen C HoganRichard W J Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.