PMID: 11914448Mar 27, 2002Paper

Low-dose dexamethasone suppression test in chronic fatigue syndrome and health

Psychosomatic Medicine
Jens GaabUlrike Ehlert

Abstract

Subtle dysregulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome have been described. The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome. In 21 patients with chronic fatigue syndrome and 21 healthy control subjects, awakening and circadian salivary free cortisol profiles were assessed over 2 consecutive days and compared with awakening and circadian salivary free cortisol profiles after administration of 0.5 mg of dexamethasone at 11:00 PM the previous day. Patients with chronic fatigue syndrome had normal salivary free cortisol profiles but showed enhanced and prolonged suppression of salivary free cortisol after the administration of 0.5 mg of dexamethasone in comparison to the control subjects. Enhanced negative feedback of the hypothalamus-pituitary-adrenal axis could be a plausible explanation for the previously described alterations in hypothalamus-pituitary-adrenal axis functioning in chronic fatigue syndrome. Because similar changes have been described in stress-related disorders, a putative role of stress in the pathogenesis of the enhanced feedback is possible.

References

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R A DressendörferC J Strasburger
Dec 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M A DemitrackP W Gold
Jan 1, 1990·Journal of Psychosomatic Research·R PowellS Wessely
Jan 1, 1987·International Journal of Psychiatry in Medicine·G S TaerkS Ozersky
Mar 1, 1987·Biological Psychiatry·M T Lowy, H Y Meltzer
Apr 1, 1995·Journal of Psychosomatic Research·E M SmetsJ C De Haes
Jul 1, 1994·Journal of Psychosomatic Research·J H VercoulenG Bleijenberg
Sep 1, 1993·Journal of Psychosomatic Research·M T HyyppäP Puukka
Aug 18, 1995·Journal of Affective Disorders·A J CleareV O'Keane
Jul 1, 1996·Psychological Medicine·T ChalderS Wessely
Jan 1, 1997·British Journal of Rheumatology·M De BandtO Meyer
Jan 1, 1997·Journal of Psychiatric Research·I E Salit
Aug 1, 1997·Psychoneuroendocrinology·I LiberzonE A Young
Jan 23, 1998·Neuropsychobiology·B WoodS Checkley
Aug 26, 1998·Clinical Endocrinology·L V ScottT G Dinan
Oct 27, 1998·Stress : the International Journal on the Biology of Stress· De Kloet ER
Jan 20, 1999·Proceedings of the Association of American Physicians·P W Gold, G P Chrousos
Apr 16, 1999·Psychosomatic Medicine·J C PruessnerC Kirschbaum
Oct 20, 1999·The American Journal of Medicine·E A WalkerJ Russo
Dec 14, 1999·Clinical Endocrinology·M Hudson, A J Cleare
Jul 8, 2000·Medical History·R B Tattersall
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·M EbrechtC Kirschbaum
Apr 6, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·J VisserL Nagelkerken

❮ Previous
Next ❯

Citations

Jun 1, 2005·Journal of Affective Disorders·W K JerjesN F Taylor
Apr 30, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Kazuhiro Tajima-PozoJosé Luis Carrasco
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Marni N SilvermanEsther M Sternberg
Sep 2, 2008·Psychoneuroendocrinology·J F van VeenF G Zitman
Sep 17, 2008·Psychosomatics·Filip Van Den Eede, Greta Moorkens
Mar 14, 2007·Seminars in Arthritis and Rheumatism·Muhammad B Yunus
Mar 24, 2007·Biological Psychology·Mieke SonnenscheinLorenz J P van Doornen
Dec 26, 2006·Journal of Psychosomatic Research·Katja WingenfeldChristine Heim
Oct 20, 2006·Psychoneuroendocrinology·Julia A GolierRachel Yehuda
Sep 4, 2008·International Journal of Methods in Psychiatric Research·Brenda W J H PenninxUNKNOWN NESDA Research Consortium
Oct 7, 2010·Psychiatry and Clinical Neurosciences·Hiroshi KunugiTadahiro Numakawa
Sep 11, 2004·Psychoneuroendocrinology·Julienne E BowerJohn L Fahey
Apr 1, 2015·Psychiatry and Clinical Neurosciences·Hiroshi KunugiShintaro Ogawa
Feb 6, 2007·Psychoneuroendocrinology·Walid K JerjesAnthony J Cleare
Feb 9, 2007·Psychoneuroendocrinology·Maike Ter WolbeekCobi J Heijnen
Oct 16, 2014·Health Care for Women International·Sharni Lee HardcastleSonya Marshall-Gradisnik
Mar 27, 2009·Psychoneuroendocrinology·Katja WingenfeldMartin Driessen
Jan 24, 2009·PLoS Computational Biology·Amos Ben-ZviGordon Broderick
Mar 28, 2012·BMC Ear, Nose, and Throat Disorders·Veerle L Simoens, Sylvie Hébert
Dec 1, 2003·Acta Neuropsychiatrica·A J Cleare
Aug 26, 2016·BMC Endocrine Disorders·Flavio A Cadegiani, Claudio E Kater
Nov 23, 2012·The Australian and New Zealand Journal of Psychiatry·Christina PhassouliotisPatrick D McGorry
Aug 1, 2003·Acta Neuropsychiatrica·Jens GaabUlrike Ehlert
Dec 6, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Santiago HerreraPatrick O McGowan
Jun 3, 2005·Neuropsychology Review·Leonard A JasonCaroline King
Feb 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Amanda D L RobertsAnthony J Cleare
Jun 15, 2019·Stress : the International Journal on the Biology of Stress·Charlotte MarkertUrs M Nater
Dec 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Urs M NaterChristine Heim
Apr 18, 2003·Endocrine Reviews·Anthony J Cleare
Nov 20, 2009·Journal of Psychosomatic Obstetrics and Gynaecology·Katja WingenfeldChristine Heim
May 3, 2011·Sleep·Khairunnessa RahmanUte Vollmer-Conna
Jul 10, 2018·Mediators of Inflammation·Megan LynnStuart Watson
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Patricia Sanders, Jakob Korf
Feb 11, 2010·Neuroscience and Behavioral Physiology·E E FomichevaE G Rybakina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.