PMID: 9192205May 1, 1997Paper

Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat

Human & Experimental Toxicology
I StottJ R Fry

Abstract

The effect of low doses of diethyldithiocarbamate (DEDC) on hepatic cytochrome P450-dependent enzyme activity and 1,3-dichloro-2-propanol (DCP) hepatotoxicity in the rat have been investigated. DEDC at a dose of 5 mg/kg selectively inhibited enzyme markers for CYP2E1 activity, and provided substantial protection against DCP hepatotoxicity. At a higher dose (25 mg/kg), DEDC also inhibited an enzyme marker for CYP1A2 activity and provided complete protection against DCP hepatotoxicity. It is concluded: (a) that DEDC at a dose of 5 mg/kg is a selective CYP2E1 inhibitor in the rat in vivo; and (b) that DCP hepatotoxicity is mediated principally by CYP2E1, with a possible contribution from CYP1A2.

References

Jul 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J H Fentem, J R Fry
Nov 1, 1990·Pharmacology & Toxicology·H IshiyamaT Hobara
Aug 1, 1990·Alcoholism, Clinical and Experimental Research·D LucasJ F Menez
Jan 1, 1989·Drug Metabolism Reviews·D R KoopD J Tierney
Aug 15, 1983·Biochemical Pharmacology·G E MillerF E Greene
Aug 30, 1994·Biochemical Pharmacology·M D BurkeR T Mayer
Apr 1, 1994·Human & Experimental Toxicology·T ShiozakiT Sugimoto
Jun 1, 1993·Liver·J HaratakeK Imazu
Jan 1, 1993·Critical Reviews in Toxicology·J L RaucyJ M Lasker
Jun 1, 1996·Free Radical Research·J LiuB N Ames
Feb 15, 1996·Environmental Toxicology and Pharmacology·A H HammondJ R Fry

❮ Previous
Next ❯

Citations

Dec 1, 2003·Environmental Toxicology and Pharmacology·Raghavendra L Ksheerasagar, Basappa B Kaliwal
Jul 27, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J R FryN W Thomas
Jul 12, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N L'HuillierR H Clothier
Jul 5, 2005·Expert Opinion on Investigational Drugs·J WuM A Zern
Jun 24, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M J GarleJ R Fry
Jun 28, 2008·Parkinsonism & Related Disorders·Carla PardiniGiovanni U Corsini
May 29, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Susanne AndresAlfonso Lampen
Jun 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Canela-XandriRamon Canela-Garayoa
Sep 26, 2014·Chemical Research in Toxicology·Suramya WaidyanathaTimothy R Fennell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.