Low-dose dobutamine stress echocardiography in children and young adults

The American Journal of Cardiology
D De WolfY Taeymans

Abstract

Dobutamine stress echocardiography has become widely accepted in the evaluation of adult patients with coronary heart disease. We wanted to assess the feasibility and the physiologic responses of stress echocardiography at low doses of dobutamine in a population of normal children and adults. Once achieved, we submitted a group of post-anthracycline patients to the test to assess the sensitivity of low-dose dobutamine stress echocardiography in the detection of cardiac dysfunction. Thirty-two healthy children and young adults (19 male and 13 female subjects, median age 15 years [range 6 to 26]) were studied. After the initial study of normal subjects, we submitted a cohort of 39 patients (18 female and 21 male, aged 6 to 25 years), who completed anthracycline chemotherapy, to the same protocol. Dobutamine was infused at rates of 0.5 to 2.5 and 5 microg/kg/min and echocardiographic measurements were obtained at rest and at the end of each stage. The test could be completed in 100% of the subjects without major complications. Statistically significant differences between resting echocardiographic values of systolic and diastolic function and values at 2.5 and 5 microg/kg/min of dobutamine were found. Moreover, dobutamine revealed...Continue Reading

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Citations

Aug 31, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Juan Carlos PlanaPatrizio Lancellotti
Sep 28, 2010·International Journal of Pediatrics·André La Gerche, Marc Gewillig
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Oct 24, 2009·Cardiology in the Young·Daniëlle Robbers-VisserWillem A Helbing
Nov 9, 2010·Pediatric Blood & Cancer·Enrico De CaroGiacomo Pongiglione
Oct 31, 2008·Journal of Magnetic Resonance Imaging : JMRI·Daniëlle Robbers-VisserWillem A Helbing
Jun 17, 2015·International Journal of Cardiology·S S M BossersW A Helbing
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Oct 16, 1999·Journal of the American College of Cardiology·D De WolfG Van Nooten
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Nov 21, 2008·Postgraduate Medicine·Ashley SimmonsDavid Meyers
Jan 1, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Roel L F van der PalenJos J M Westenberg
Aug 26, 2010·Current Opinion in Pediatrics·Willem A HelbingDaniëlle Robbers-Visser

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