PMID: 6971822Jan 1, 1981Paper

Low dose effect of ionizing radiation on incorporation of iododeoxyuridine into bone marrow cells

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
N ZamboglouL E Feinendegen

Abstract

The reduction of the incorporation of IUdR in bone marrow cells depends on the time after irradiation and on te microenvironment of the cells. The strongest effect is observed 4 hours after irradiation. For absorbed doses above 40 rad, whole-body irradiated mice were more sensitive with respect to depression of IUdR incorporation in bone marrow cells, when the bone marrow cells were labelled in vivo, and less sensitive for in vitro labelling. The converse was observed for very small doses of 1 rad and below. Such small doses resulted in a significant depression of IUdR incorporation after in vivo irradiation and in vitro labelling and showed no effect at all after in vivo irradiation and in vivo labelling. The least effect of radiation was observed after both irradiation and labelling in vitro. Although the mechanisms are not fully understood, the biological results and microdosimetric considerations indicate that at the smallest doses the effect is due to functional changes of cellular organelles which control intracellular mechanisms. A working hypothesis is proposed for the reduction of IUdR incorporation at low doses as being due to functional changes of the cellular membranes.

References

Dec 1, 1975·Journal of Cellular Physiology·D K Myers, L E Feinendegan
Jan 1, 1978·Progress in Experimental Tumor Research·H W ChenH J Heiniger
Jul 8, 1975·Biochemical and Biophysical Research Communications·R A Walters, C E Hildebrand
Jun 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·L E FeinendegenW L Hughes
Jun 3, 1967·Nature·E FrindelF Vassort

❮ Previous
Next ❯

Citations

Apr 6, 2006·The British Journal of Radiology·B F WallJ R Meara
Sep 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·L E Feinendegen, H Mühlensiepen
Feb 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S Chwalinski, C S Potten
Apr 7, 2007·Journal of the American College of Radiology : JACR·Donald P Frush, Kimberly Applegate
Mar 24, 2007·Experimental Hematology·Ludwig E FeinendegenRonald D Neumann
Mar 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E RommelK Gersonde
Dec 19, 2007·Radiation and Environmental Biophysics·Ludwig FeinendegenEberhard O Voit
Jan 1, 1993·Radiation and Environmental Biophysics·K I AltmanL E Feinendegen
Jan 26, 2016·Health Physics·Ludwig E Feinendegen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.