PMID: 11910619Mar 26, 2002Paper

Low-dose esterified estrogens (0.3 mg/day): long-term and short-term effects on menopausal symptoms and quality of life in postmenopausal women

Climacteric : the Journal of the International Menopause Society
R W RebarJ Mortola

Abstract

To study the impact of low-dose unopposed esterified estrogens on menopausal symptoms and quality of life. In a long-term, 2-year, randomized, double-blind, placebo-controlled study, 204 postmenopausal women were treated with esterified estrogens 0.3 mg daily or placebo. Menopausal symptoms were assessed with a modified Kupperman index at baseline, 3, 6 and thereafter every 6 months. In a second 12-week, open-label, short-term pilot study, 25 postmenopausal women with moderate to severe vasomotor symptoms were treated with esterified estrogens 0.3 mg daily for 12 weeks. Vasomotor symptoms and quality of life were assessed using the Greene scale and Quality of Life Menopause Scale (QUALMS). In the long-term study, significant (p < 0.05) reductions in total symptom scores were observed at each time point with esterified estrogens compared with placebo. Somatic symptom scores (hot flushes, night sweats, vaginal dryness) decreased significantly (p < 0.01) in patients treated with esterified estrogens 0.3 mg compared to baseline and placebo. In the short-term, open-label pilot study, the incidence of vasomotor symptoms was significantly (p < 0.01) reduced with esterified estrogens 0.3 mg from week 4 until the study end. Significant ...Continue Reading

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Citations

Jan 26, 2005·Menopause : the Journal of the North American Menopause Society·Linda KokYvonne T van der Schouw
Jul 5, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Debi SmolinskiLinda S Kim
May 2, 2009·Expert Opinion on Pharmacotherapy·Wen Shen, Vered Stearns
Jun 6, 2013·The Cochrane Database of Systematic Reviews·Carolina O NastriWellington P Martins
Jun 14, 2008·Menopause : the Journal of the North American Menopause Society·Carolina Kimie MoriyamaTais Tinucci
Oct 2, 2004·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists Women's Health Care Physicians
Mar 28, 2013·Climacteric : the Journal of the International Menopause Society·A R GenazzaniK Gude
Jul 9, 2014·Obstetrics and Gynecology·Susan D ReedKatherine A Guthrie
Nov 1, 2003·Journal of Women's Health·Carolyn Crandall
Oct 21, 2004·The Cochrane Database of Systematic Reviews·A H MaclennanV Moore
Aug 25, 2011·Climacteric : the Journal of the International Menopause Society·S AedoC Irribarra
Feb 20, 2007·Menopause : the Journal of the North American Menopause Society·Suzanne C HoJean L F Woo

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