Low dose gamma-irradiation differentially modulates antioxidant defense in liver and lungs of Balb/c mice

International Journal of Radiation Biology
P K AvtiS C Sharma

Abstract

To evaluate the effect of low-dose (<50 cGy) whole body ?-irradiation on the antioxidant defense system in the liver and the lungs of mice at various post-irradiation intervals. Male Balb/c mice, 5 - 6 weeks of age, were divided into irradiated and non-irradiated groups. Whole body irradiation was done with gamma-rays from a (60)Co source at doses of 10, 25 and 50 cGy (48.78 cGy/min). Lipid peroxidation and antioxidant status were measured in the liver and the lungs at 4, 12 and 24 h after irradiation. Lipid peroxidation increased by 1.38 and 2.0 fold in lung and liver respectively at 12 h after exposure to 25 cGy. Whole body exposure to 25 and 50 cGy significantly (p < 0.05) increased the hepatic reduced glutathione at 4 h. Reduced glutathione continued to rise until 12 h and returned to the basal level at 24 h, whereas in the lungs it remained elevated until 24 h at 10 and 25 cGy. Antioxidant enzymes activities for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase increased by 1.22, 1.13, 1.22 and 1.11 fold respectively (p < 0.05) in the liver at 4 h after exposure to 50 cGy and remained elevated at almost the same level up to 12 h after exposure. Surprisingly these antioxidant defense enzymes r...Continue Reading

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Citations

Oct 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Uma S BhartiyaBadanidiyoor S Rao
Apr 13, 2010·Antioxidants & Redox Signaling·Neelam KhaperPawan K Singal
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Oct 17, 2020·Radiation Research·Carmen I RiosAndrea L DiCarlo
Nov 3, 2020·Frontiers in Genetics·Eunguk ShinBuHyun Youn

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